6315-94-2

Basic information

• Product Name: 2,4-Dichloro-quinoline-3-carboxylic acid ethyl ester
• Synonyms: 2,4-dichloro-3-quinolinecarboxylic acid ethyl ester;AH-034/34345020;BAS 00525761;BB_SC-0202;NSC21038;Oprea1_425128;Oprea1_683131;ZINC00040529
• CAS NO: 6315-94-2
• Molecular Formula: C₁₂H₉Cl₂NO₂
• Molecular Weight: 270.12
• Product Categories: pharmacetical
• Mol File: 6315-94-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 354.8°C at 760 mmHg
• Flash Point: 168.4°C
• Appearance: /
• Density: 1.384g/cm³
• Vapor Pressure: 3.27E-05mmHg at 25°C
• Refractive Index: 1.618
• CAS DataBase Reference: 2,4-Dichloro-quinoline-3-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dichloro-quinoline-3-carboxylic acid ethyl ester(6315-94-2)
• EPA Substance Registry System: 2,4-Dichloro-quinoline-3-carboxylic acid ethyl ester(6315-94-2)

Safety Data

• Hazardous Substances Data: 6315-94-2(Hazardous Substances Data)

Usage

General Description

2,4-Dichloro-quinoline-3-carboxylic acid ethyl ester is a chemical compound that belongs to the quinoline derivative class. It is a yellow solid that is soluble in organic solvents. 2,4-Dichloro-quinoline-3-carboxylic acid ethyl ester is used as an intermediate in the synthesis of pharmaceuticals and agricultural chemicals. It is an ethyl ester derivative of 2,4-dichloro-quinoline-3-carboxylic acid, which is a key component in the production of various drugs and pesticides. The compound exhibits biological activity and is being researched for its potential use in medical and agricultural applications.

InChI:InChI=1/C12H9Cl2NO2/c1-2-17-12(16)9-10(13)7-5-3-4-6-8(7)15-11(9)14/h3-6H,2H2,1H3

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 53341-66-5 ethyl 3-oxo-3-(phenylamino)propionate 
• 36239-09-5 ethyl chlorocarbonylacetate 
• 148237-81-4 ethyl 4-hydroxy-1-nonyl-2-oxo-1,2-dihydroquinoline-3-carboxylate 
• 52851-60-2 ethyl 1-ethyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate 
• 206363-41-9 N-methoxycarbonylacetyl-anthranilic acid methyl ester 
• 105-53-3 diethyl malonate 
• 134-20-3 2-carbomethoxyaniline 
• 40059-53-8 ethyl 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate 
• 169216-62-0 2-oxo-3-ethoxycarbonyl-4-acetoxyquinoline 
• 79575-01-2 2-hydroxy-4-methoxy-quinoline-3-carboxylic acid ethyl ester 
• 40059-53-8 ethyl 2,4-dihydroxyquinoline-3-carboxylate 

Downstream Products

• 99429-64-8 4-chloro-2-hydroxy-quinoline-3-carboxylic acid ethyl ester 
• 73776-19-9 1H-4-hydroxy-2-oxoquinoline-3-carboxylic acid methyl ester 
• 213181-22-7 1H-4-chloro-2-oxoquinoline-3-carboxylic acid methyl ester 
• 1186191-41-2 N-[1-(2-Hydroxyethyl)piperidin-4-yl]-3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]quinoline-2-carboxamide 
• 1186231-63-9 2-[4-({[3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]quinolin-2-yl]carbonyl}amino)piperidin-1-yl]-2-oxoethyl acetate 
• 1186231-64-0 N-[1-(Hydroxyacetyl)piperidin-4-yl]-3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]quinoline-2-carboxamide 
• 1396621-49-0 C₂₉H₃₄N₄O₄ 
• 1186189-14-9 ethyl 4-[(2-ethoxy-2-oxoethyl) (methyl)amino]-1-(4-methoxybenzyl)-2-oxo-1,2-dihydroquinoline-3-carboxylate 
• 1186188-23-7 ethyl 4-chloro-2-oxo-1-(2-oxo-2-phenylethyl)-1,2-dihydroquinoline-3-carboxylate 
• 863586-42-9 ethyl 4-chloro-1-(4-methoxybenzyl)-2-oxo-1,2-dihydroquinoline-3-carboxylate 
• 1186188-24-8 ethyl 3-hydroxy-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydrothieno[3,2-c]quinoline-2-carboxylate 
• 1186188-38-4 ethyl 3-hydroxy-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydrofuro[3,2-c]quinoline-2-carboxylate 
• 1186188-41-9 ethyl 4-[(2-ethoxy-2-oxoethyl)(methyl)amino]-2-oxo-1-(2-oxo-2-phenylethyl)-1,2-dihydroquinoline-3-carboxylate 
• 1186188-42-0 ethyl 3-hydroxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]quinoline-2-carboxylate 

Relevant articles and documents

Synthesis method of 2,4-dichloroquinoline compound

The invention discloses a synthesis method of a 2,4-dichloroquinoline compound, belonging to the technical field of organic synthesis. The method comprises the following steps: at room temperature, mixing triphosgene and triphenylphosphine oxide, dissolving the mixture in an organic solvent, stirring for 10-30 minutes, adding an alpha-substituted acetyl arylamine compound, heating the reaction system to 90-130 DEG C, continuously stirring and reacting for 3-6 hours, and post-treating the obtained reaction liquid to obtain the 2,4-dichloroquinoline compound. The method for synthesizing the 2, 4-dichloroquinoline compound has the advantages of few steps, high yield and safer and more convenient operation; meanwhile, the triphenylphosphine oxide used in the reaction can be recycled, so that the emission of phosphorus-containing wastes is greatly reduced, and the method is suitable for industrial production.

Facile synthesis of 4-substituted-2-quinolinone-3-carboxylic acid ethyl esters

An efficient route for the synthesis of 4-substituted-2-quinolinone-3- carboxylic acid ethyl esters has been developed through Suzuki or Sonogashira reactions. The advantages of the method include high yields, operational simplicity, and suitability for m

4-Hydroxyquinol-2-ones. 85*. Synthesis of 2-chloro-4- hydroxyquinoline-3-carboxylic acid ethyl ester

The behavior of 2-chloro-4-hydroxy- and 4-chloro-2-oxoquinoline-3- carboxylic acids under acid catalyzed esterification conditions with methanol has been studied. A method is proposed for obtaining 2-chloro-4- hydroxyquinoline-3-carboxylic acid ethyl ester.