6317-37-9 Usage
Description
5-Nitrothiophene-2-carboxylic acid is an organic compound characterized by its solid state and a molecular structure that features a nitro group attached to a thiophenecarboxylic acid. 5-Nitrothiophene-2-carboxylic acid is known for its potential applications in the pharmaceutical and chemical industries due to its unique properties and reactivity.
Uses
Used in Pharmaceutical Industry:
5-Nitrothiophene-2-carboxylic acid is used as a reagent for the preparation of benzothiophene amides, which serve as nicotinamide ribosyltransferase inhibitors. These inhibitors possess potential antitumor and anticancer activities, making them valuable in the development of novel therapeutic agents for cancer treatment.
Used in Chemical Synthesis:
5-Nitrothiophene-2-carboxylic acid also functions as an intermediate in various organic transformations, contributing to the synthesis of a wide range of chemical compounds. Its versatility in chemical reactions makes it a useful building block for creating complex molecules with diverse applications across different industries.
Synthesis Reference(s)
Canadian Journal of Chemistry, 44, p. 2881, 1966 DOI: 10.1139/v66-428Journal of Medicinal Chemistry, 34, p. 2112, 1991
Check Digit Verification of cas no
The CAS Registry Mumber 6317-37-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,3,1 and 7 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 6317-37:
(6*6)+(5*3)+(4*1)+(3*7)+(2*3)+(1*7)=89
89 % 10 = 9
So 6317-37-9 is a valid CAS Registry Number.
InChI:InChI=1/C5H3NO4S/c7-5(8)3-1-2-4(11-3)6(9)10/h1-2H,(H,7,8)/p-1
6317-37-9Relevant articles and documents
ANTIVIRAL COMPOUNDS, COMPOSITIONS AND METHODS OF USE
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Page/Page column 24-25, (2021/06/26)
Provided herein are antiviral compounds having the structure of Formula (I) and compositions thereof for use in the treatment of viral infection. In particular, the compounds of Formula (I) are capable of interfering with the export of viral mRNA processing as reflected in the altered accumulation of viral RNA isoforms as well as transport from the nucleus to the cytoplasm. Such compounds show a reduction of HIV, adenovirus and coronavirus infection of cells. The invention provides compounds that may be suitable for the treatment of HIV/AIDS. (Formula (I))
Raltitrexed pharmaceutical composition and preparation method thereof
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Paragraph 0049; 0050, (2018/04/02)
The invention relates to a raltitrexed pharmaceutical composition which is high in safety and a preparation method thereof. The raltitrexed pharmaceutical composition comprises raltitrexed and thiophene related substances, wherein the content of the thiophene related substances is not higher than 0.3%. The raltitrexed pharmaceutical composition is good in safety, effectiveness and stability and can relieve the blood toxicity of the raltitrexed to a certain degree.
DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS
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Paragraph 0317; 0318, (2014/01/07)
Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols according to formula (I) are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme.