6318-30-5

Basic information

• Product Name: (S)-4,5-ISOPROPYLIDENE-1-PENTANOL
• Synonyms: 2,2-dimethyl-1,3-Dioxolane-4-propanol
• CAS NO: 6318-30-5
• Molecular Formula: C₈H₁₆O₃
• Molecular Weight: 160.21084
• Mol File: 6318-30-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 221°Cat760mmHg
• Flash Point: 103.7°C
• Appearance: /
• Density: 0.996g/cm³
• Vapor Pressure: 0.0227mmHg at 25°C
• Refractive Index: 1.433
• PKA: 15.04±0.10(Predicted)
• CAS DataBase Reference: (S)-4,5-ISOPROPYLIDENE-1-PENTANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4,5-ISOPROPYLIDENE-1-PENTANOL(6318-30-5)
• EPA Substance Registry System: (S)-4,5-ISOPROPYLIDENE-1-PENTANOL(6318-30-5)

Safety Data

• Hazardous Substances Data: 6318-30-5(Hazardous Substances Data)

Usage

Description

(S)-4,5-ISOPROPYLIDENE-1-PENTANOL, also known as isopropylidene pentanol, is a colorless liquid with a molecular formula of C8H18O and a pleasant odor. It is a chemical compound commonly used in the pharmaceutical and chemical industries as a building block for the synthesis of various compounds. Known for its high purity and stability, it is a versatile and valuable chemical in a range of applications.

Uses

Used in Pharmaceutical and Chemical Industries:
(S)-4,5-ISOPROPYLIDENE-1-PENTANOL is used as a building block for the synthesis of various compounds due to its versatile chemical properties and stability.
Used in Cosmetic Products:
(S)-4,5-ISOPROPYLIDENE-1-PENTANOL is used as a solvent and a fragrance ingredient in cosmetic products, benefiting from its pleasant odor and compatibility with other ingredients.
Used as a Solvent:
(S)-4,5-ISOPROPYLIDENE-1-PENTANOL is used as a solvent in various applications, taking advantage of its ability to dissolve a wide range of substances and its compatibility with different materials.
Considering its safety and lack of significant health risks when handled and used properly, (S)-4,5-ISOPROPYLIDENE-1-PENTANOL is a reliable chemical for use in multiple industries.

InChI:InChI=1/C8H16O3/c1-8(2)10-6-7(11-8)4-3-5-9/h7,9H,3-6H2,1-2H3

Upstream product

• 21461-84-7 (2S)-tetrahydro-5-oxofuran-2-carboxylic acid 
• 56-86-0 L-glutamic acid 
• 14697-46-2 1,2,5-pentanetriol 
• 77-76-9 2,2-dimethoxy-propane 
• 67-64-1 acetone 
• 96392-13-1 (2R)-4-Bromo-1,2-O-isopropylidenebutane-1,2-diol 
• 110-87-2 3,4-dihydro-2H-pyran 
• 173152-85-7 (R)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propionic acid 
• 5470-86-0 1,2,5-triacetoxypentane 
• 173152-84-6 ethyl (R)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propionate 
• 36326-39-3 Ethyl 4,5-O-isopropylidene-(S)-4,5-dihydroxypentanoate 

Downstream Products

• 69380-64-9 rac-2,2-dimethyl-4-(3'-hydroxypropyl)-1,3-dioxolan toluene-p-sulphonate 
• 1020733-14-5 4-[3-(2,2-dimethyl-1,3-dioxolan-4-yl)propoxy]-2,3-dimethylpyridine 1-oxide 
• 132970-45-7 (R)-2-tert-Butoxycarbonylamino-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-pentanoic acid benzyl ester 
• 132970-44-6 (S)-2-tert-Butoxycarbonylamino-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-pentanoic acid benzyl ester 
• 132970-36-6 (Z)-2-tert-Butoxycarbonylamino-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-pent-2-enoic acid benzyl ester 
• 132990-94-4 (E)-2-tert-Butoxycarbonylamino-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-pent-2-enoic acid benzyl ester 
• 132970-50-4 Hexadecanoic acid (1R,5R)-5-benzyloxycarbonyl-5-hexadecanoylamino-1-hexadecanoyloxymethyl-pentyl ester 
• 132990-96-6 Hexadecanoic acid (1R,5S)-5-benzyloxycarbonyl-5-hexadecanoylamino-1-hexadecanoyloxymethyl-pentyl ester 
• 163060-85-3 [(2R,5S,2'R,5'R,2''S,5''S)-5''-(tert-Butyl-diphenyl-silanyloxymethyl)-dodecahydro-[2,2';5',2'']terfuran-5-yl]-methanol 
• 163060-86-4 [(2S,5S,2'S,5'R,2''S,5''S)-5''-(tert-Butyl-diphenyl-silanyloxymethyl)-dodecahydro-[2,2';5',2'']terfuran-5-yl]-methanol 
• 163002-19-5 tert-Butyl-[(Z)-6-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-hex-3-enyloxy]-diphenyl-silane 
• 163002-20-8 tert-Butyl-((Z)-(R)-6-oxiranyl-hex-3-enyloxy)-diphenyl-silane 
• 177411-58-4 4-(3-Benzylsulfanyl-propyl)-2,2-dimethyl-[1,3]dioxolane 
• 177411-59-5 5-Benzylsulfanyl-pentane-1,2-diol 

Relevant articles and documents

Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule

Indirubins have been identified as potent ATP-competitive protein kinase inhibitors. Structural modifications in the 5-and 3′-position have been extensively investigated, but the impact of substituents in 5′-position is not equally well-studied. Here, we report the synthesis of new indirubin 3′-and 5′-derivatives in the search of water-soluble indirubins by introducing basic centers. Antiproliferative activity of all compounds in tumor cells was evaluated along with kinase inhibition of selected compounds. The results show the 3′-position to tolerate large substituents without compromising activity, whereas bulk and rigid substituents in 5′-position appear unfavorable. Screening molecular targets of water-soluble 3′-oxime ethers revealed 6ha as preferential inhibitor of insulin-like growth factor 1 receptor (IGF-1R) in a panel of 22 protein kinases and in cells. Consistently, 6ha inhibited tumor cell growth in the NCI 60 cell line panel and induced apoptosis. The results indicate that the 5′-position provides limited space for chemical modifications and identify 6ha as a potent water-soluble indirubin-based IGF-1R inhibitor.

Methods for synthesis of substituted tetrahydrofuran compound

The invention includes inter alia new methods for preparation of the pharmaceutically active compound 2-(4-fluorophenoxymethyl)-5-(4-N-hydroxyureidyl-1-butynyl)-tetrahydrofuran and precursors thereof.

Deprotection of tetrahydropyranyl ethers with montmorillonite K-10 clay in methanol

A variety of tetrahydropyranyl (THP) ethers are removed by Montmorillonite K-10 clay in methanol at room temperature to give alcohols. It has been shown that the THP ethers carrying epoxy, methoxymethoxy (MOMO), tertbutyldiphenylsiloxy (TBDP-SO-), acetoxy (AcO-) and benzoyloxy (BzO-) functionalities are stable under the conditions, while the ethers carrying ketal, tertbutyldimethylsioxy (TBSO-) and β,β,β-trichloroethylimidoxy [CCl3C(=NH)O-] functionalities are unstable.