631899-58-6

Basic information

• Product Name: (2R,3R,4S,5S)-3,4-Bis-benzyloxy-2-benzyloxymethyl-5-(2,4,5-trifluoro-phenyl)-tetrahydro-furan
• Synonyms: (2R,3R,4S,5S)-3,4-Bis-benzyloxy-2-benzyloxymethyl-5-(2,4,5-trifluoro-phenyl)-tetrahydro-furan
• CAS NO: 631899-58-6
• Molecular Weight: 534.575
• Mol File: 631899-58-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2R,3R,4S,5S)-3,4-Bis-benzyloxy-2-benzyloxymethyl-5-(2,4,5-trifluoro-phenyl)-tetrahydro-furan(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R,4S,5S)-3,4-Bis-benzyloxy-2-benzyloxymethyl-5-(2,4,5-trifluoro-phenyl)-tetrahydro-furan(631899-58-6)
• EPA Substance Registry System: (2R,3R,4S,5S)-3,4-Bis-benzyloxy-2-benzyloxymethyl-5-(2,4,5-trifluoro-phenyl)-tetrahydro-furan(631899-58-6)

Safety Data

• Hazardous Substances Data: 631899-58-6(Hazardous Substances Data)

Upstream product

• 327-52-6 1-bromo-2,4,5-trifluorobenzene 
• 14233-64-8 (3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-dihydro-furan-2-one 
• 631899-56-4 (2S,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-2-(2,4,5-trifluoro-phenyl)-tetrahydro-furan-2-ol 

Relevant articles and documents

Three different fluoro- or chloro-substituted 1'-deoxy-1'-phenyl-β-d- ribofuranoses

Crystal structures are reported for three fluoro- or chloro-substituted 1'-deoxy-1'-phenyl-β-d-ribofuranoses, namely 1'-deoxy-1'-(2,4,5- trifluorophenyl)-β-d-ribofuranose, C11H11F 3O4, (I), 1'-deoxy-1'-(2,4,6-trifluorophenyl)-β-d- ribofuranose, C11H11F3O4, (II), and 1'-(4-chlorophenyl)-1'-deoxy-β-d-ribofuranose, C11H 13ClO4, (III). The five-membered furanose ring of the three compounds has a conformation between a C2'-endo,C3'-exo twist and a C2'-endo envelope. The ribofuranose groups of (I) and (III) are connected by intermolecular O - H?O hydrogen bonds to six symmetry-related molecules to form double layers, while the ribofuranose group of (II) is connected by O - H?O hydrogen bonds to four symmetry-related molecules to form single layers. The O?O contact distance of the O - H?O hydrogen bonds ranges from 2.7172(15) to 2.8895(19)A?. Neighbouring double layers of (I) are connected by a very weak intermolecular C - F?π contact. The layers of (II) are connected by one C - H?O and two C - H?F contacts, while the double layers of (III) are connected by a C - H?Cl contact. The conformations of the molecules are compared with those of seven related molecules. The orientation of the benzene ring is coplanar with the H - C1' bond or bisecting the H - C1' - C2' angle, or intermediate between these positions. The orientation of the benzene ring is independent of the substitution pattern of the ring and depends mainly on crystal-packing effects.

Synthesis of modified RNA-oligonucleotides for structural investigations

RNA exhibits a higher structural diversity than DNA and is an important molecule in biology of life. It shows a number of secondary structures such as duplexes, hairpin loops, bulges, internal loops etc. However, in natural RNA, bases are limited to the f