6320-51-0

Basic information

• Product Name: 2,4-Thiazolidinedione, 5-p-methoxybenzylidene-
• Synonyms: 2,4-Thiazolidinedione, 5-p-methoxybenzylidene-;NSC 31205
• CAS NO: 6320-51-0
• Molecular Formula: C₁₁H₉NO₃S
• Molecular Weight: 235.26
• Mol File: 6320-51-0.mol
• Article Data: 85

Chemical Properties

• Appearance: /
• Density: 1.391g/cm³
• Refractive Index: 1.667
• CAS DataBase Reference: 2,4-Thiazolidinedione, 5-p-methoxybenzylidene-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Thiazolidinedione, 5-p-methoxybenzylidene-(6320-51-0)
• EPA Substance Registry System: 2,4-Thiazolidinedione, 5-p-methoxybenzylidene-(6320-51-0)

Safety Data

• Hazardous Substances Data: 6320-51-0(Hazardous Substances Data)

Usage

General Description

5-p-methoxybenzylidene-2,4-thiazolidinedione, also known as pioglitazone, is a chemical compound that is primarily used as a medication for treating type 2 diabetes. Developed by Takeda Pharmaceuticals and sold under the brand name Actos, it works by making the body’s cells more responsive to insulin, thus regulating the blood sugar level. The compound can be used alone or in combination with other medications. Despite its effectiveness, it has been associated with several side effects, including potentially increased risk of heart failure, bladder cancer, and bone fractures in females.

InChI:InChI=1/C11H9NO3S/c1-15-8-4-2-7(3-5-8)6-9-10(13)12-11(14)16-9/h2-6H,1H3,(H,12,13,14)

Upstream product

• 2295-31-0 thiazoline-2,4-dione 
• 123-11-5 4-methoxy-benzaldehyde 
• 4334-74-1 4-methoxybenzylidene thiosemicarbazone 
• 79-11-8 chloroacetic acid 
• 38728-36-8 5-(4-methoxy-benzylidene)-4-thioxo-thiazolidin-2-one 
• 55111-58-5 5-(4-Methoxyphenylmethylene)-4-oxo-2-piperidino-2-thiazoline 
• 124-41-4 sodium methylate 
• 36937-45-8 5-(4-Methoxyphenylmethylene)-2-morpholino-2-thiazolin-4-one 
• 28996-11-4 5-(4-methoxy-benzylidene)-2-methylsulfanyl-thiazol-4-one 
• 75-03-6 ethyl iodide 
• 71995-45-4 5-(4-Methoxyphenylmethylene)-2,4-dioxothiazolidine potassium salt 
• 99819-42-8 3-allyl-5-(4-methoxybenzylidene)thiazolidine-2,4-dione 
• 67-56-1 methanol 
• 151-50-8 potassium cyanide 

Downstream Products

• 83749-89-7 5-(4-Methoxybenzyliden)-3-hydroxymethylthiazolidinon-2,4 
• 74942-61-3 2-mercapto-3-(4-methoxyphenyl)-N-(N-methyl-N-phenylhydrazinocarbonyl)propenamide 
• 74948-39-3 3-hydrazino-6-(4-methoxybenzyl)-1,2,4-triazin-5(2H)-one 
• 74942-51-1 N-(hydrazinocarbonyl)-2-hydrazono-3-(4-methoxyphenyl)propanamide 
• 184840-77-5 5-[(4-methoxyphenyl)-methyl]thiazolidine-2,4-dione 
• 99819-42-8 3-allyl-5-(4-methoxybenzylidene)thiazolidine-2,4-dione 
• 87910-43-8 3-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-thiazolidine-2,4-dione 
• 87910-37-0 Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-{5-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-2,4-dioxo-thiazolidin-3-yl}-tetrahydro-furan-3-yl ester 
• 1119274-20-2 7-(4-methoxyphenyl)-5-thioxo-4,5,6,7-tetrahydro-3H-thiazolo[4,5-d]pyrimidin-2-one 
• 464882-41-5 2-{[5-(4-methoxybenzylidene)-2,4-dioxothiazolidin-3-yl]methyl}-1H-benzimidazole 
• 1421637-73-1 5-(p-methoxybenzylidine)-2,4-thiazolidinedione 
• 1421637-74-2 5-(p-methoxybenzylidine)-2,4-thiazolidinedione 
• 1421637-75-3 5-(p-methoxybenzylidine)-2,4-thiazolidinedione 
• 1421637-70-8 C₁₉H₁₇N₃O₆S₂ 

Relevant articles and documents

The interaction of thiazolidine-2,4-dione with an aromatic aldehyde under microwave irradiation

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Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms

Different 2,4-thiazolidinedione-tethered coumarins 5a–b, 10a–n and 11a–d were synthesised and evaluated for their inhibitory action against the cancer-associated hCAs IX and XII, as well as the physiologically dominant hCAs I and II to explore their selec

Synthesis and characterization of pine-cone derived carbon-based solid acid: A green and recoverable catalyst for the synthesis of pyra-no_pyrazole, amino-benzochromene, amidoalkyl naphthol and thiazoli-dinedione derivatives

In this report, SO3H-functionalized Carbon nanoparticles (Pine-SO3H) with high acid density have been synthesized by the thermal treatment of sulfuric acid with Pine-Cone as carbon-based at 180oC in a sealed autoclave in a

Synthesis and antimicrobial activity of a new series of thiazolidine-2,4-diones carboxamide and amino acid derivatives

Novel thiazolidine-2,4-dione carboxamide and amino acid derivatives were synthesized in excellent yield using OxymaPure/N,N'-diisopropylcarbodimide coupling methodology and were characterized by chromatographic and spectrometric methods, and elemental ana