632298-55-6

Basic information

• Product Name: C₁₁H₁₉N₃O₃
• CAS NO: 632298-55-6
• Molecular Weight: 241.29
• Mol File: 632298-55-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₁H₁₉N₃O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₁H₁₉N₃O₃(632298-55-6)
• EPA Substance Registry System: C₁₁H₁₉N₃O₃(632298-55-6)

Safety Data

• Hazardous Substances Data: 632298-55-6(Hazardous Substances Data)

Upstream product

• 1433194-33-2 C₁₂H₁₉NO₅ 
• 74-89-5 methylamine 

Downstream Products

• 845290-58-6 2-methyl-2,8-diazaspiro[5.5]undecane 

Relevant articles and documents

Synthesis and differential functionalisation of pyrrolidine and piperidine based spirodiamine scaffolds

The synthesis and differential substitution/protection of a series of spirodiamine scaffolds are described. Methods for selective access to the two mono-N-methyl isomers based on 2,7-diazaspiro[4.5]decane are also described. Key precursors associated with this chemistry are prone to rearrangement and methods for circumventing this issue are reported. While direct mono-carbamoylation (Boc) was not efficient, selective deprotection of doubly Boc-protected derivatives derived from symmetrical diamines provided mono-Boc variants. N-Arylation, exemplified by a series of monosubstituted spirodiamines incorporating the 2-chloro-5-pyridyl moiety, which is a privileged nicotinic agonist substructure, has also been carried out to provide monoarylated secondary and tertiary spirodiamines variants.