6323-99-5

Basic information

• Product Name: 2-amino-4-phosphonobutyric acid
• Synonyms: 2-Amino-4-phosphonobutanoic acid;DL-2-Amino-4-phosphonobutyric Acid, 98.0+ % (HPLC)
• CAS NO: 6323-99-5
• Molecular Formula: C₄H₁₀NO₅P
• Molecular Weight: 183.1
• Mol File: 6323-99-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 229-231 °C(Solv: ethanol (64-17-5); water (7732-18-5))
• Boiling Point: 491.7±55.0 °C(Predicted)
• Appearance: /
• Density: 1.628±0.06 g/cm3(Predicted)
• PKA: 2.19±0.10(Predicted)
• CAS DataBase Reference: 2-amino-4-phosphonobutyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-4-phosphonobutyric acid(6323-99-5)
• EPA Substance Registry System: 2-amino-4-phosphonobutyric acid(6323-99-5)

Safety Data

• Hazardous Substances Data: 6323-99-5(Hazardous Substances Data)

Usage

Description

DL-AP4 is a broad-spectrum glutamatergic antagonist. DL-AP4 (2.5 mM) inhibits electrically stimulated synaptic transmission in rabbit hippocampal slices. It also depresses depolarizations induced by NMDA , L-homocysteate, or kainate in isolated frog spinal cord when used at a concentration of 1 mM. DL-AP4 (0.2 mM) inhibits the accumulation of inositol induced by ibotenate , quisqualate, L-glutamate, and L-aspartate in rat hippocampal slices.

Upstream product

• 86554-31-6 2-Amino-4-(dimethoxy-phosphoryl)-butyric acid methyl ester 
• 5324-30-1 diethyl 2-bromoethylphosphonate 
• 81167-39-7 methyl N-(diphenylmethylene)glycinate 

Downstream Products

• 288607-57-8 2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoic acid 
• 995-32-4 tetraethyl ethylenebis(phosphonate) 
• 93960-22-6 amino-2 diethylphosphono-4 butyrate d'ethyle 
• 155179-92-3 2-(N-benzyloxycarbonylamino)-4-phosphonobutanoic acid 
• 97847-01-3 2-N-benzoylamino-4-phosphonobutyric acid 
• 66508-32-5 3-(N-acetyl-N-hydroxyamino)propylphosphonic acid 
• 63-37-6 cytidine monophosphate 
• 1346431-49-9 CMP-5'-3-aminopropylphosphonate 
• 63-38-7 cytidine diphosphate 

Relevant articles and documents

Synthesis and characterization of intermediate and transition-state analogue inhibitors of γ-gutamyl peptide ligases

The phosphonodifluoromethyl ketone and phosphonofluoridate derivatives of L-glutamic acid were synthesized and characterized as analogues of the γ-glutamyl phosphate intermediate and the tetrahedral transition state, respectively, for the inhibition of γ-

PREPARATION D'ACIDES AMINOCARBOXY-ALKYLPHOSPHONIQUES OPTIQUEMENT ACTIFS

In aqueous solution ω-formylalkylphosphonates in the presence of hydrogen cyanide and (S) (-) α-methylbenzylamine give optically active aminonitriles with an enantiomeric excess of 50percent.Phosphonic aminonitriles are submitted to acid hydrolysis, then esterified and debenzylated without any epimerization.The separation is performed either with the acid or with the ester.All the operations are monitored by NMR (1H, 13C, 31P) and whenever possible, by GC.