63237-88-7

Basic information

• Product Name: Pyrazolo[1,5-a]pyridine-2-carboxylic acid
• Synonyms: PYRAZOLO[1,5-A]PYRIDINE-2-CARBOXYLIC ACID;Pyrazolo[1,5-a]pyridine-2-carboxylic acid, tech;H-pyrazolo[1,5-a]pyridine-2-carboxylic acid;pyrazolo[1,5-a]pyridine-2-carb;Pyraxolo[1,5-a]pyridine-2-carboxylicacid;5-HYDROXYINDOLINE-2-CARBOXYLIC ACID ETHYL ESTER;Pyrazolo[1,5-a]pyridine-2-carboxylic acid 97%+;2-Carboxypyrazolo[1,5-a]pyridine
• CAS NO: 63237-88-7
• Molecular Formula: C₈H₆N₂O₂
• Molecular Weight: 162.15
• Product Categories: Carboxylic Acids;Carboxylic Acids;Fused Ring Systems;Heterocycle-Pyridine series
• Mol File: 63237-88-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 189 °C
• Appearance: /
• Density: 1.418 g/cm³
• Refractive Index: 1.676
• Storage Temp.: 2-8°C
• PKA: -3.82±0.41(Predicted)
• CAS DataBase Reference: Pyrazolo[1,5-a]pyridine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrazolo[1,5-a]pyridine-2-carboxylic acid(63237-88-7)
• EPA Substance Registry System: Pyrazolo[1,5-a]pyridine-2-carboxylic acid(63237-88-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 22-26-36/37/39
• Hazardous Substances Data: 63237-88-7(Hazardous Substances Data)

Usage

Chemical Properties

White to yellow solid

InChI:InChI=1/C8H6N2O2/c11-8(12)7-5-6-3-1-2-4-10(6)9-7/h1-5H,(H,11,12)

Upstream product

• 25275-41-6 N-iminopyridinium ylide 
• 110-86-1 pyridine 
• 5825-71-8 pyrazolo<1,5-a>pyridine-2,3-dicarboxylic acid dimethyl ester 
• 63237-87-6 pyrazolo[1,5-a]pyridine-2,3-dicarboxylic acid 

Downstream Products

• 151831-21-9 methyl pyrazolo[1,5-a]pyridine-2-carboxylate 
• 1398582-68-7 3-({[(1R)-1-(2,4-difluorophenyl)propyl](pyrazolo[1,5-a]pyridin-2-ylcarbonyl)amino}methyl)benzoic acid 
• 1398584-58-1 C₂₆H₂₃F₂N₃O₃ 
• 1398582-67-6 3-({[(1R)-1-(4-fluorophenyl)ethyl](pyrazolo[1,5-a]pyridin-2-ylcarbonyl)amino}methyl)benzoic acid 
• 1398584-56-9 C₂₅H₂₂FN₃O₃ 
• 1398582-78-9 3-({[(1R)-1-(2,4-difluorophenyl)ethyl](pyrazolo[1,5-a]pyridin-2-ylcarbonyl)amino}methyl)benzoic acid 
• 1398584-03-6 C₂₅H₂₁F₂N₃O₃ 
• 1628848-24-7 N-((1s,4s)-4-(2-(4'-(((3S,5R)-3,5-dimethylpiperazin-1-yl)methyl)biphenyl-3-yloxy)-5-fluoronicotinamido)cyclohexyl)pyrazolo[1,5-a]pyridine-2-carboxamide trifluoroacetic acid salt 
• 76943-47-0 pyrazolo[1,5-a]pyridin-2-ylmethanol 
• 1428968-66-4 1-(1H-indol-3-yl)-2-((3-methoxyphenyl)amino)-2-(pyrazolo[1,5-a]pyridin-2-yl)ethan-1-one 
• 1428972-46-6 3-methoxy-N-(pyrazolo[1,5-a]pyridin-2-ylmethylene)aniline 

Relevant articles and documents

PYRIMIDONE DERIVATIVES CONTAINING TWO FUSED BICYCLIC RINGS

The invention relates to a compound of formula (I), wherein the variables are defined in the specification. It also relates to a pesticidal mixture comprising the compound of formula (I); the use of compounds of formula (I) as an agrochemical pesticide; a method for combating or controlling invertebrate pests, a method for protecting growing plants from attack or infestation by invertebrate pests, seed comprising a compound of the formula (I); the use of a compound of the formula (I) for protecting growing plants from attack or infestation by invertebrate pests; and a method for treating or protecting an animal from infestation or infection by invertebrate pests.

Inhibitor HBSC11 for hepatitis B virus targeted human La protein and derivative and application thereof

The invention belongs to the field of pharmaceuticals and relates to an inhibitor taking human La protein as a target and anti-hepatitis-B-virus effect of a derivative thereof. Through structural modification of the inhibitor taking the human La protein as the target, a human La protein targeted inhibiting compound shown as a formula (I) is obtained by screening. Experiments verify that the compound has high antiviral activity, has La protein targeting effect, can be used for druggability study of new drug resistant to hepatitis B virus and is expected to be developed into new non-nucleoside anti-HBV drug.

Rationally based efficacy tuning of selective dopamine D4 receptor ligands leading to the complete antagonist 2-[4-(4-Chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-α]pyridine (FAUC 213)

-