63242-15-9

Basic information

• Product Name: (4'-chloro-[1,1'-biphenyl]-4-yl)(phenyl)methanone
• Synonyms: (4'-chloro-[1,1'-biphenyl]-4-yl)(phenyl)methanone
• CAS NO: 63242-15-9
• Molecular Weight: 292.765
• Mol File: 63242-15-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (4'-chloro-[1,1'-biphenyl]-4-yl)(phenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4'-chloro-[1,1'-biphenyl]-4-yl)(phenyl)methanone(63242-15-9)
• EPA Substance Registry System: (4'-chloro-[1,1'-biphenyl]-4-yl)(phenyl)methanone(63242-15-9)

Safety Data

• Hazardous Substances Data: 63242-15-9(Hazardous Substances Data)

Upstream product

• 1679-18-1 4-Chlorophenylboronic acid 
• 134-85-0 4-chlorobenzophenone 
• 106-39-8 bromochlorobenzene 
• 1137-42-4 4-Hydroxybenzophenone 
• 98-88-4 benzoyl chloride 
• 2051-62-9 4'-biphenyl chloride 

Downstream Products

• 63242-36-4 4'-Chloro-4-(chloro-phenyl-methyl)-biphenyl 

Relevant articles and documents

Pd-Catalysed Suzuki-Miyaura cross-coupling of aryl chlorides at low catalyst loadings in water for the synthesis of industrially important fungicides

The Suzuki-Miyaura coupling reaction of electron-poor aryl chlorides in the synthesis of crop protection-relevant active ingredients in water is disclosed. Optimisation of the reaction conditions allowed running the reaction with 50 ppm of Pd-catalyst loading without an additional organic solvent in the cross-coupling reaction step in short reaction times. The system was optimised for the initial cross-coupling step of the large scale produced fungicides Boscalid, Fluxapyroxad and Bixafen up to 97% yield. It is also shown that the Suzuki-Miyaura reaction can be easily scaled up to 50 g using a simple product separation and purification using environmentally benign solvents in the work-up. To show the usability of this method, it was additionally applied in the three-step synthesis of the desired active ingredients.