63254-50-2

Basic information

• Product Name: acetic acid, 2-diazo-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester
• Synonyms: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl diazoacetate
• CAS NO: 63254-50-2
• Molecular Formula: C₁₂H₂₀N₂O₂
• Molecular Weight: 224.2994
• Mol File: 63254-50-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: acetic acid, 2-diazo-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: acetic acid, 2-diazo-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester(63254-50-2)
• EPA Substance Registry System: acetic acid, 2-diazo-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester(63254-50-2)

Safety Data

• Hazardous Substances Data: 63254-50-2(Hazardous Substances Data)

Upstream product

• 16832-20-5 (1R,2S,5R)-menthol bromoacetate 
• 127236-74-2 (1R,2S,5R)-(-)-menthyl diazoacetoacetate 
• 110-46-3 isopentyl nitrite 
• 7377-98-2 (-)-menthyl chloroacetate 
• 2216-51-5 (-)-menthol 
• 63254-60-4 (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-aminoacetate 
• 14661-69-9 p-toluenesulfonylhydrazone glyoxylic acid chloride 

Downstream Products

• 139494-83-0 2-Butyl-cycloprop-2-enecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 132098-63-6 2-(4-Methoxy-phenyl)-3-methyl-cyclopropanecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 139494-80-7 2-Methoxymethyl-cycloprop-2-enecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 158918-28-6 (1R,2S,5R)-menthyl 2-(acetoxymethyl)cycloprop-2-en-carboxylate 
• 40999-13-1 (1S)-trans (l)-menthyl 2,2-dimethyl-3-(2-methyl-1-propenyl)-1-cyclopropanecarboxylate 

Relevant articles and documents

Ethynylbenziodazolones (EBZ) as Electrophilic Alkynylation Reagents for the Highly Enantioselective Copper-Catalyzed Oxyalkynylation of Diazo Compounds

Ethynylbenziodoxol(on)e (EBX) cyclic hypervalent iodine reagents are now established reagents for the alkynylation of radicals and nucleophiles, yet they present limited possibilities for further structure and reactivity modification. Herein, the first synthesis is reported for the corresponding ethynylbenziodazolone (EBZ) reagents, in which the oxygen atom in the iodoheterocycle is replaced by a nitrogen atom. The substituent on the nitrogen enables further fine-tuning of the reagent structure and reactivity. EBZ reagents are obtained easily from the corresponding benzamides by using a one-step procedure, and display reactivity comparable to that of EBX reagents. In particular, they are applied in an asymmetric copper-catalyzed oxyalkynylation of diazo compounds, which proceeds in high yield and enantioselectivity for a broad range of substituents on the diazo compounds and the alkyne.

Enantioselective Copper-Catalyzed Oxy-Alkynylation of Diazo Compounds

Enantioselective catalytic methods allowing the addition of both a nucleophile and an electrophile onto diazo compounds give a fast access into important building blocks. Herein, we report the highly enantioselective oxyalkynylation of diazo compounds usi

N,N′-ditosylhydrazine: A convenient reagent for facile synthesis of diazoacetates

A novel entry to the synthesis of diazoacetates is disclosed. A variety of diazoacetates were synthesized from the corresponding bromoacetates by treatment with N,N′-ditosylhydrazine in moderate to high yields. Ease of operation with the stable crystalline reagent as well as a short reaction time offer a useful alternative to the conventional methods.