6327-59-9

Basic information

• Product Name: H-ASP(OBZL)-OBZL HCL
• Synonyms: L-ASPARTIC ACID DIBENZYL ESTER HYDROCHLORIDE;L-ASPARTIC ACID-ALPHA, BETA-DIBENZYL ESTER HYDROCHLORIDE;L-ASPARTIC ACID ALPHA,BETA-DIBENZYL ESTER HYDROCHLORIDE SALT;H-ASP(OBZL)-OBZL HCL;H-L-Asp(Bzl)-OBzl*HCl;L-Aspartic acid 1,4-bis-benzyl ester hydrochloride;H-Asp(OBzl)-OBzlCl;L-Aspartic acid, bis(phenylMethyl) ester, hydrochloride
• CAS NO: 6327-59-9
• Molecular Formula: C₁₈H₁₉NO₄*ClH
• Molecular Weight: 349.81
• Product Categories: Amino Acids
• Mol File: 6327-59-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: 124-125 °C
• Boiling Point: 455.3°C at 760 mmHg
• Flash Point: 180.6°C
• Appearance: /Solid
• Density: 1.205g/cm³
• Vapor Pressure: 1.78E-08mmHg at 25°C
• Refractive Index: 1.574
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: H-ASP(OBZL)-OBZL HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-ASP(OBZL)-OBZL HCL(6327-59-9)
• EPA Substance Registry System: H-ASP(OBZL)-OBZL HCL(6327-59-9)

Safety Data

• Hazardous Substances Data: 6327-59-9(Hazardous Substances Data)

Usage

General Description

H-ASP(OBZL)-OBZL HCL is a chemical compound that consists of N-(9-fluorenylmethoxycarbonyl) (Fmoc) protected amino acid H-ASP(OBZL)-OBZL and hydrochloric acid (HCL). The Fmoc group acts as a protecting group to prevent unwanted reactions during chemical synthesis. The compound is commonly used in peptide synthesis and solid-phase peptide chemistry as a building block for the production of peptides. It is an important tool for the efficient and controlled assembly of peptides in chemical and biological research. It is typically handled and stored with care due to its potential reactivity and health hazards.

InChI:InChI=1/C18H19NO4/c19-16(18(21)23-13-15-9-5-2-6-10-15)11-17(20)22-12-14-7-3-1-4-8-14/h1-10,16H,11-13,19H2

Upstream product

• 56-84-8 L-Aspartic acid 
• 100-51-6 benzyl alcohol 
• 104-15-4 toluene-4-sulfonic acid 
• 2886-33-1 dibenzyl L-aspartate toluene-4-sulphonate 
• 7536-58-5 BOC-L-aspartic acid 4-benzyl ester 
• 80974-42-1 (S)-N-tert-butyloxycarbonylaspartic acid dibenzyl ester 

Downstream Products

• 79974-09-7 (S)-2-{(S)-4-Benzyloxycarbonyl-4-[4-(benzyloxycarbonyl-methyl-amino)-benzoylamino]-butyrylamino}-succinic acid dibenzyl ester 
• 79974-12-2 (S)-2-{(S)-4-Benzyloxycarbonyl-2-[4-(benzyloxycarbonyl-methyl-amino)-benzoylamino]-butyrylamino}-succinic acid dibenzyl ester 
• 1246972-75-7 N-(3-benzyloxycarbonyl-β-carbolin-1-yl)ethyl-L-aspartic acid dibenzyl ester 
• 871266-67-0 dibenzyl (S)-2-{2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]acetylamino}succinate 
• 1283599-32-5 C₃₂H₂₁NO₉ 
• 1283599-53-0 C₃₂H₂₃NO₁₀ 
• 1283599-60-9 C₅₀H₃₈N₂O₁₂ 

Relevant articles and documents

A class of novel carboline intercalators: Their synthesis, in vitro anti-proliferation, in vivo anti-tumor action, and 3D QSAR analysis

Based on DOCK scores 18 N-(3-benzyloxycarbonylcarboline-1-yl)ethylamino acid benzylesters (6a-r) were synthesized as anti-tumor agents. Their IC 50 values against five human carcinoma cell lines ranged from 11.1 μM to more than 100 μM. The in vivo assay identified five derivatives of them had no anti-tumor action, the anti-tumor activity of nine derivatives of them equaled that of cytarabine, and the anti-tumor activity of three derivatives of them was higher than that of cytarabine. The UV and fluorescence spectra, as well as the relative viscosity and melting temperature measurements of calf thymus DNA (CT DNA) with and without the representative compound suggested that DNA intercalation could be their action mechanism. The 3D QSAR analysis of N-(3-benzyloxycarbonylcarboline-1-yl)ethylamino acid benzylesters (6a-r) revealed that their in vivo anti-tumor activity significantly depends on the molecular electrostatic and steric fields of the side chain of the amino acid residue.