63271-86-3

Basic information

• Product Name: 3-Mercaptophenylacetic Acid, 90%
• Synonyms: 3-MERCAPTOPHENYLACETIC ACID:90%;3-Mercapto-benzeneacetic Acid;2-(3-Mercaptophenyl)acetic acid
• CAS NO: 63271-86-3
• Molecular Formula: C₈H₈O₂S
• Molecular Weight: 168.21
• Product Categories: Intermediates;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 63271-86-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 100-103°C
• Boiling Point: 336°C at 760 mmHg
• Flash Point: 157°C
• Appearance: /
• Density: 1.299g/cm³
• Vapor Pressure: 4.54E-05mmHg at 25°C
• Refractive Index: 1.62
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 4.20±0.10(Predicted)
• Stability: Store in Freezer
• CAS DataBase Reference: 3-Mercaptophenylacetic Acid, 90%(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Mercaptophenylacetic Acid, 90%(63271-86-3)
• EPA Substance Registry System: 3-Mercaptophenylacetic Acid, 90%(63271-86-3)

Safety Data

• Hazardous Substances Data: 63271-86-3(Hazardous Substances Data)

Usage

Description

3-Mercaptophenylacetic Acid, 90% is an off-white solid that serves as a valuable synthetic intermediate in the development of innovative anti-inflammatory agents. Its unique chemical structure allows for the creation of new compounds with potential therapeutic applications.

Uses

Used in Pharmaceutical Industry:
3-Mercaptophenylacetic Acid, 90% is used as a synthetic intermediate for the development of novel anti-inflammatory agents. Its chemical properties make it a promising candidate for the creation of new compounds that can effectively alleviate inflammation and associated conditions.
Used in Research and Development:
3-Mercaptophenylacetic Acid, 90% is also utilized in research and development settings, where scientists and chemists explore its potential applications in various fields, including pharmaceuticals, material science, and chemical engineering. Its unique properties and reactivity enable the synthesis of new compounds with diverse applications.

InChI:InChI=1/C8H8O2S/c9-8(10)5-6-2-1-3-7(11)4-6/h1-4,11H,5H2,(H,9,10)

Upstream product

• 22958-99-2 2-(4-(chlorosulfonyl)phenyl)acetic acid 
• 1877-73-2 3-nitro-benzeneacetic acid 
• 887354-92-9 2-(3-((ethoxycarbonothioyl)thio)phenyl)acetic acid 

Downstream Products

• 1354653-09-0 2-(3-((3-((2-((5-phenylpyrimidin-2-yl)carbamoyl)-4-(piperidin-1-yl)-phenyl)carbamoyl)benzyl)thio)phenyl)acetic acid 
• 259191-92-9 methyl 2-(3-(chlorosulfonyl)phenyl)acetate 
• 1359979-68-2 [3-(2-methyl-1H-indol-3-ylsulfanyl)-phenyl]-acetic acid 
• 1359979-74-0 [3-(6-chloro-2-methyl-1H-indol-3-ylsulfanyl)-phenyl]-acetic acid 
• 1359979-73-9 [3-(6-chloro-1,2-dimethyl-1H-indol-3-ylsulfanyl)-phenyl]-acetic acid 
• 1359979-72-8 [3-(1,2-dimethyl-1H-indol-3-ylsulfanyl)-phenyl]-acetic acid 
• 1359979-70-6 [3-(6-fluoro-2-methyl-1H-indol-3-ylsulfanyl)-phenyl]-acetic acid 
• 1359980-44-1 [3-(6-chloro-2-methyl-1H-indol-3-ylsulfanyl)-phenyl]-acetic acid ethyl ester 
• 1359979-69-3 [3-(2-oxo-propylsulfanyl)-phenyl]-acetic acid 
• 1363179-02-5 2-[3-(ethylsulfonyl)phenyl]-N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yl]acetamide 
• 1363179-55-8 2-(3-(ethylsulfonyl)phenyl)acetic acid 
• 1363179-53-6 ethyl 2-(3-(ethylsulfonyl)phenyl)acetate 
• 1363179-51-4 ethyl 2-(3-(ethylthio)phenyl)acetate 
• 1354721-84-8 2-(3-((3-((4-chloro-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)phenyl)acetic acid 

Relevant articles and documents

ROR GAMMA (RORY) MODULATORS

The present invention relates to compounds according to Formula I: Wherein: A11 - A14 are N or CR11, CR12, CR13, CR14, respectively, with the proviso that no more than two of the four positions A can be simultaneously N; R1 is C(1-6)alkyl, C(3-6)cycloalkyl, C(3-6)cycloalkylC(1 -3)alkyl, (di)C(1-6)alkylamino, (di)C(3-6)cycloalkylamino or (di)(C(3-6)cycloalkylC(1 -3)alkyl)amino, with all carbon atoms of alkyl groups optionally substituted with one or more F and all carbon atoms of cycloalkyl groups optionally substituted with one or more F or methyl; R2 and R3 are independently H, F, methyl, ethyl, hydroxy, methoxy or R2 and R3 together is carbonyl, all alkyl groups, if present, optionally being substituted with one or more F; R4 is H or C(1-6)alkyl; R5 is H, hydroxyethyl, methoxyethyl, C(1-6)alkyl, C(6-10)aryl, C(6-10)arylC(1-3)alkyl, C(1 -9)heteroaryl, C(1-9)heteroarylC(1-3)alkyl, C(3-6)cycloalkyl, C(3-6)cycloalkylC(1 -3)alkyl, C(2-5)heterocycloalkyl or C(2-5)heterocycloalkylC(1-3)alkyl, all groups optionally substituted with one or more F, CI, C(1-2)alkyl, C(1-2)alkoxy or cyano; the sulfonyl group with R1 is represented by one of R7, R8 or R9; the remaining R6-RH are independently H, halogen, C(1-3)alkoxy, (di)C(1-3)alkylamino or C(1-6)alkyl, all of the alkyl groups optionally being substituted with one or more F; and Ri5 and Ri6 are independently H, C(1-6)alkyl, C(3-6)cycloalkyl, C(3-6)cycloalkylC(1-3)alkyl, C(6-10)aryl, C(6-10)arylC(1-3)alkyl, C(1-9)heteroaryl, C(1-9)heteroarylC(1-3)alkyl, C(2-5)heterocycloalkyl or C(2-5)heterocycloalkylC(1-3)alkyl, all groups optionally substituted with one or more F, CI, C(1-2)alkyl, C(1-2)alkoxy or cyano. The compounds can be used as inhibitors of RORy and are useful for the treatment of RORy mediated diseases.

Organic thiol metal-free stabilizers and plasticizers for halogen-containing polymers

Organic thiol compounds based on pentaerythritol and dipentaerythritol are described herein. More specifically, the compounds of the present invention are mixed esters of pentaerythritol and dipentaerythritol having at least one sulfhydryl group and preferably a plurality of sulfhydryl groups as well as at least one non-thiol-containing group. The organic thiol compounds are utilized to plasticize and/or heat stabilize halogen-containing polymer compositions especially poly(vinyl chloride) compositions. The compositions are substantially free or free of metal-based stabilizers, Lewis acids and terpenes. The compounds of the present invention are ideally utilized in polymers normally susceptible to deterioration and color change which can occur during processing of the polymer or exposure of the polymer to certain environments and surprisingly also serve as excellent plasticizers.