63307-63-1 Usage
Description
[DMET2, PRO5]-ENKEPHALINAMIDE is a synthetic peptide compound derived from the endogenous opioid peptide enkephalin. It functions as an opioid receptor agonist, playing a significant role in regulating pain perception and emotional response. [DMET2 , PRO5 ]-ENKEPHALINAMIDE possesses analgesic and anti-nociceptive properties, which enable it to reduce the perception of pain and the response to painful stimuli. Additionally, it has been studied for its potential role in modulating stress and anxiety. The chemical structure of [DMET2, PRO5]-ENKEPHALINAMIDE allows for its specificity and affinity to opioid receptors, making it a promising candidate for the development of new pain management therapies.
Uses
Used in Pharmaceutical Industry:
[DMET2, PRO5]-ENKEPHALINAMIDE is used as an analgesic agent for the treatment of pain. Its ability to reduce the perception of pain and the response to painful stimuli makes it a valuable compound in the development of new pain management therapies.
Used in Research and Development:
[DMET2, PRO5]-ENKEPHALINAMIDE is used as a research tool for studying the mechanisms of pain perception, emotional response, and the role of opioid receptors in these processes. [DMET2 , PRO5 ]-ENKEPHALINAMIDE can help researchers better understand the underlying biology and develop more effective treatments for pain and related conditions.
Used in Stress and Anxiety Management:
[DMET2, PRO5]-ENKEPHALINAMIDE is used as a potential therapeutic agent for modulating stress and anxiety. Its effects on the opioid receptors may contribute to the development of new treatments for stress-related disorders and anxiety conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 63307-63-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,3,0 and 7 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 63307-63:
(7*6)+(6*3)+(5*3)+(4*0)+(3*7)+(2*6)+(1*3)=111
111 % 10 = 1
So 63307-63-1 is a valid CAS Registry Number.
InChI:InChI=1/C30H40N6O6S/c1-43-15-13-23(35-28(40)22(31)16-20-9-11-21(37)12-10-20)29(41)33-18-26(38)34-24(17-19-6-3-2-4-7-19)30(42)36-14-5-8-25(36)27(32)39/h2-4,6-7,9-12,22-25,37H,5,8,13-18,31H2,1H3,(H2,32,39)(H,33,41)(H,34,38)(H,35,40)/t22-,23+,24-,25-/m0/s1
63307-63-1Relevant articles and documents
Role of the sugar moiety on the opioid receptor binding and conformation of a series of enkephalin neoglycopeptides
Rosa, Mònica,Gonzalez-Nunez, Verónica,Barreto-Valer, Katherine,Marcelo, Filipa,Sánchez-Sánchez, Julia,Calle, Luis P.,Arévalo, Juan C.,Rodríguez, Raquel E.,Jiménez-Barbero, Jesús,Arsequell, Gemma,Valencia, Gregorio
, p. 2260 - 2265 (2017)
Glycosylation by simple sugars is a drug discovery alternative that has been explored with varying success for enhancing the potency and bioavailability of opioid peptides. Long ago we described two O-glycosides having either β-Glucose and β-Galactose of (D-Met2, Pro5)-enkephalinamide showing one of the highest antinociceptive activities known. Here, we report the resynthesis of these two analogs and the preparation of three novel neoglycopeptide derivatives (α-Mannose, β-Lactose and β-Cellobiose). Binding studies to cloned zebrafish opioid receptors showed very small differences of affinity between the parent compound and the five glycopeptides thus suggesting that the nature of the carbohydrate moiety plays a minor role in determining the binding mode. Indeed, NMR conformational studies, combined with molecular mechanics calculations, indicated that all glycopeptides present the same major conformation either in solution or membrane-like environment. The evidences provided here highlight the relevance for in vivo activity of the conjugating bond between the peptide and sugar moieties in opioid glycopeptides.
