6332-42-9

Basic information

• Product Name: 9-benzyl-N,N-dimethyl-9H-purin-6-amine
• Synonyms: 9-Benzyl-N,N-dimethyl-9H-purin-6-amine; 9H-purin-6-amine, N,N-dimethyl-9-(phenylmethyl)-; Purine, 9-Benzyl-6-dimethylamino
• CAS NO: 6332-42-9
• Molecular Formula: C₁₄H₁₅N₅
• Molecular Weight: 253.3024
• Mol File: 6332-42-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 455.3°C at 760 mmHg
• Flash Point: 229.2°C
• Density: 1.22g/cm³
• Vapor Pressure: 1.77E-08mmHg at 25°C
• Refractive Index: 1.658
• CAS DataBase Reference: 9-benzyl-N,N-dimethyl-9H-purin-6-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 9-benzyl-N,N-dimethyl-9H-purin-6-amine(6332-42-9)
• EPA Substance Registry System: 9-benzyl-N,N-dimethyl-9H-purin-6-amine(6332-42-9)

Safety Data

• Hazardous Substances Data: 6332-42-9(Hazardous Substances Data)

Upstream product

• 1928-76-3 9-benzyl-6-chloro-9H-purine 
• 68-12-2 N,N-dimethyl-formamide 
• 5451-40-1 2,6 dichloropurine 
• 87-42-3 6-chloropurine 
• 79064-26-9 9-benzyl-2,6-dichloro-9H-purine 
• 100-39-0 benzyl bromide 
• 100-46-9 benzylamine 
• 61667-16-1 benzyl-(6-chloropyrimidin-4-yl)-amine 
• 944062-68-4 N-benzyl-N',N'-dimethyl-5-nitrosopyrimidin-4,6-diamine 
• 944062-58-2 N-benzyl-6-chloro-5-nitrosopyrimidin-4-amine 
• 123811-47-2 N⁶-benzyl-N⁴,N⁴-dimethylpyrimidine-4,5,6-triamine 
• 122-51-0 orthoformic acid triethyl ester 
• 115204-53-0 (9-Benzyl-2-chloro-9H-purin-6-yl)-dimethyl-amine 
• 938-55-6 6-Dimethylaminopurine 

Downstream Products

• 123811-23-4 9-benzyl-8-bromo-6-(dimethylamino)-9H-purine 
• 123811-28-9 9-benzyl-6-(dimethylamino)-7,9-dihydro-8H-purin-8-one 
• 123811-27-8 9-benzyl-6-(dimethylamino)-8-(methylamino)-9H-purine 
• 123811-25-6 9-benzyl-6-(dimethylamino)-8-methoxy-9H-purine 
• 123811-26-7 9-benzyl-6,8-bis(dimethylamino)-9H-purine 

Relevant articles and documents

8-Bromination of 2,6,9-trisubstituted purines with pyridinium tribromide

2,6,9-Trisubstituted purines are brominated in high yields using pyridinium tribromide as the brominating reagent. This procedure works excellently for electron-rich purines having electron-donating substituents at the 2- and 6-positions. The use of pyridinium tribromide, a crystalline alternative to elemental bromine, improves the bromination procedure for this type of substrate as the reagent is easy to handle and the work-up and purification procedures are simplified.

Effect of substituent structure on pyrimidine electrophilic substitution

In an investigation into the electrophilic nitrosation reactions of a series of 4,6-disubstituted pyrimidine derivatives, a subtle interplay between the electronic nature of the C-4 and C-6 substituents and reactivity was found where these were chloro-, mono- or disubstituted amino groups. Effects such as the presence of an aryl group or two alkyl groups on the amino moiety impede the progress of the reaction despite the presence of a second activating group.

SYNTHESIS OF N,N,9-TRISUBSTITUTED ADENINES UNDER CONDITIONS OF PHASE-TRANSFER CATALYSIS

Alkylation of N-mono- and N,N-disubstituted adenines by 2,6-dichlorobenzyl chlorides under the conditions of phase-transfer catalysis in the benzene-50percent aqueous sodium hydroxide system takes place regioselectively with the formation of the corresponding N,N,9-trisubstituted adenines (60-80percent).The isomeric N,N,3-trisubstituted adenines are also formed.The N,9-disubstituted adenines are alkylated regiospecifically under analogous conditions and give N,N,9-trisubstituted adenines with quantitative yields.