633283-64-4

Basic information

• Product Name: 3-(4-BOC-piperazino)-2-chloropyridine
• Synonyms: 3-(4-BOC-piperazino)-2-chloropyridine;4-(2-CHLORO-3-PYRIDINYL)-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER
• CAS NO: 633283-64-4
• Molecular Formula: C₁₄H₂₀ClN₃O₂
• Molecular Weight: 297.7805
• Mol File: 633283-64-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-BOC-piperazino)-2-chloropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-BOC-piperazino)-2-chloropyridine(633283-64-4)
• EPA Substance Registry System: 3-(4-BOC-piperazino)-2-chloropyridine(633283-64-4)

Safety Data

• Hazardous Substances Data: 633283-64-4(Hazardous Substances Data)

Usage

Structure

Contains a pyridine ring with a chloro substituent (2-chloropyridine) and a piperazine ring substituted with a BOC (tert-butyloxycarbonyl) protecting group.

Usage

Commonly employed as an intermediate in the synthesis of pharmaceuticals and agrochemicals.

Medical Studies

Investigated for potential therapeutic applications in cancer treatment and neurological disorders.

Insecticidal Properties

Explored for its effectiveness as an insecticide.

Crop Protection

Investigated for potential use as a crop protection agent.

Upstream product

• 78607-36-0 2-chloro-3-iodopyridine 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 52200-48-3 3-bromo-2-chloropyridine 

Downstream Products

• 1607802-84-5 1-(4-methoxyphenoxy)-3-[4-[2-(4-pyridyl)-3-pyridyl]piperazin-1-yl]-2-propanol 
• 1607802-83-4 1-(4-methoxyphenoxy)-3-[4-[2-(3-pyridyl)-3-pyridyl]piperazin-1-yl]-2-propanol 
• 1607802-87-8 (S)-1-(4-methoxyphenoxy)-3-[4-[2-(4-pyridyl)-3-pyridyl]piperazin-1-yl]-2-propanol 
• 1607802-86-7 (R)-1-(4-methoxyphenoxy)-3-[4-[2-(4-pyridyl)-3-pyridyl]piperazin-1-yl]-2-propanol 
• 1377551-45-5 C₂₃H₃₁N₃O₂ 

Relevant articles and documents

SUBSTITUTED PYRIDINE-PIPERAZINYL ANALOGUES AS RSV ANTIVIRAL COMPOUNDS

The invention concerns novel substituted pyridine-piperazinyl analogues of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection.

SUBSTITUTED PIPERAZINYL PYRAZINES AND PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS

The present invention provides selective 5-HT7 receptor antagonist compounds of Formula (I) and their use in the treatment of migraine: where A is C(H)= or N=; m is 0, 1 or 2; R1 is optionally substituted phenyl, optionally substituted pyrazol-4-yl; optionally substituted imidazolyl, optionally substituted pyridyl, or thienyl; R2 is hydrogen or methyl; and R3 and R4 are as defined herein.

Selective Amination of Polyhalopyridines Catalyzed by a Palladium-Xantphos Complex

(Matrix presented) Amination of 5-bromo-2-chloropyridine (1a) catalyzed by a palladium-Xantphos complex predominately gives 5-amino-2-chloropyridine product 3a in 96% isolated yield and excellent chemoselectivity (3a/4a = 97:3). Amination of 2,5-dibromopyridine (11) under the same conditions exclusively affords 2-amino-5-bromopyridine 4a.