63329-53-3

Basic information

• Product Name: Lobenzarit
• Synonyms: LOBENZARIT;LOBENZARIT DISODIUM;BENZOIC ACID, 2-[(2-CARBOXYPHENYL)AMINO]-4-CHLORO-, DISODIUM SALT;2-(2-CARBOXY-PHENYLAMINO)-4-CHLORO-BENZOIC ACID;4-Chloro-2，2Liminodibenzoic acid;Carfenil;4-Chloro-2,2'-iminodibenzoic acid;4-Chloro-2-(2-carboxyphenylamino)benzoic acid
• CAS NO: 63329-53-3
• Molecular Formula: C₁₄H₁₀ClNO₄
• Molecular Weight: 291.69
• Mol File: 63329-53-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: >306°
• Boiling Point: 481 °C at 760 mmHg
• Flash Point: 244.7 °C
• Appearance: /
• Density: 1.515 g/cm³
• Vapor Pressure: 4.62E-10mmHg at 25°C
• Refractive Index: 1.699
• PKA: 3.46±0.36(Predicted)
• CAS DataBase Reference: Lobenzarit(CAS DataBase Reference)
• NIST Chemistry Reference: Lobenzarit(63329-53-3)
• EPA Substance Registry System: Lobenzarit(63329-53-3)

Safety Data

• Hazardous Substances Data: 63329-53-3(Hazardous Substances Data)

Usage

Description

Lobenzarit is a non-steroidal anti-inflammatory drug (NSAID) with immunomodulatory properties. It is a derivative of anthraquinone and exhibits anti-inflammatory, analgesic, and antipyretic effects. Lobenzarit is used to manage inflammation and pain associated with various conditions, including rheumatoid arthritis and other autoimmune disorders.

Uses

Used in Antirheumatic Applications:
Lobenzarit is used as an antirheumatic agent for the treatment of arthritis. It helps to reduce inflammation, pain, and swelling in the joints, improving the overall quality of life for patients suffering from this condition.
Used in Immunomodulation:
Lobenzarit is used as an immunomodulator to regulate the immune system's response in various autoimmune and inflammatory disorders. Its immunosuppressive properties help to alleviate symptoms and prevent further damage to the affected tissues.
Used in Pharmaceutical Industry:
Lobenzarit is used as a drug for the treatment of rheumatoid arthritis and other inflammatory conditions. Its chemical scaffold has also been repurposed to target tryptophan biosynthesis in Mycobacterium tuberculosis, indicating its potential for further therapeutic applications in the pharmaceutical industry.

InChI:InChI=1/C14H10ClNO4/c15-8-5-6-10(14(19)20)12(7-8)16-11-4-2-1-3-9(11)13(17)18/h1-7,16H,(H,17,18)(H,19,20)

Upstream product

• 118-92-3 anthranilic acid 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 50-84-0 2,4 dichlorobenzoic acid 
• 123-51-3 i-Amyl alcohol 
• 7440-44-0 pyrographite 

Downstream Products

• 1422064-45-6 4-chloro-N'-(4-methoxybenzylidene)-2-{2-[2-(4-methoxybenzylidene)hydrazinecarbonyl]phenylamino}benzohydrazide 
• 1422064-44-5 4-chloro-N'-(4-hydroxy-3,5-dimethylbenzylidene)-2-{2-[2(4-hydroxy-3,5-dimethylbenzylidene)hydrazinecarbonyl]phenylamino}benzohydrazide 
• 1422064-43-4 4-chloro-N'-(4-hydroxybenzylidene)-2-{2-[2(4-hydroxybenzylidene)hydrazinecarbonyl]phenylamino}benzohydrazide 
• 1422064-42-3 4-chloro-N'-(4-chlorobenzylidene)-2-{2-[2-(4-chlorobenzylidene)hydrazinecarbonyl]phenylamino}benzohydrazide 
• 1422064-41-2 4-chloro-2-[2-(hydrazinecarbonyl)phenylamino]benzohydrazide 
• 1422064-59-2 2-{4-chloro-2-[2-(2-(phenylcarbamothioyl)hydrazinecarbonyl)phenylamino]benzoyl}-N-phenylhydrazinecarbothioamide 
• 1422064-58-1 2-{4-chloro-2-[2-(2-(cyclohexylcarbamothioyl)hydrazinecarbonyl)phenylamino]benzoyl}-N-cyclohexylhydrazinecarbothioamide 
• 1422064-57-0 2-{4-chloro-2-[2-(2-(ethylcarbamothioyl)hydrazinecarbonyl)phenylamino]benzoyl}-N-ethylhydrazinecarbthioamide 
• 1422064-56-9 4-chloro-N'-[1-(4-hydroxyphenyl)propylidene]-2-{2-[2-(1-(4-hydroxyphenyl)propylidene)hydrazinecarbonyl]phenylamino}benzohydrazide 
• 1422064-55-8 4-chloro-N'-(1-phenylpropylidene)-2-{2-[2-(1-phenylpropylidene)hydrazinecarbonyl]phenylamino}benzohydrazide 
• 1422064-54-7 4-chloro-N'-(1-p-tolylethylidene)-2-{2-[2-(1-p-tolylethylidene)hydrazinecarbonyl]phenylamino}benzohydrazide 
• 1422064-53-6 4-chloro-N'-[1-(4-methoxyphenyl)ethylidene]-2-{2-[2-(1-(4-methoxyphenyl)ethylidene)hydrazinecarbonyl]phenylamino}benzohydrazide 
• 1422064-52-5 4-chloro-N'-[1-(4-hydroxyphenyl)ethylidene]-2-{2-[2-(1-(4-hydroxyphenyl)ethylidene)hydrazinecarbonyl]phenylamino}benzohydrazide 
• 1422064-51-4 N'-[1-(4-bromophenyl)ethylidene]-2-{2-[2-(1-(4-bromophenyl)ethylidene)hydrazinecarbonyl]phenylamino}-4-chlorobenzohydrazide 

Relevant articles and documents

A nitrogen hetero-cycloalkyl amino quinacridineone-4-amide compound and its preparation method and application

The invention provides an azo-heteroaromatic cycloalkylaminoacridone-4-amide compound which is shown in a formula I or a formula II as shown in the specification, as well as a preparation method and application thereof. In the formula I and the formula II

Molecular design, synthesis and biological research of novel pyridyl acridones as potent DNA-binding and apoptosis-inducing agents

A series of novel pyridyl acridone derivatives comprised of a pseudo-five-cyclic system to extend the π-conjugated acridone chromophore, were designed and synthesized as potent DNA binding antitumor compounds. Most synthesized compounds displayed good act

Potential antitumor agents. 38. 3-Substituted 5-carboxamido derivatives of amsacrine

The synthesis and biological evaluation of a series of 3-substituted 5-carboxamido derivatives of amsacrine (m-AMSA) are described. This series was developed as the result of previous quantitative structure-activity relationship (QSAR) studies of the antitumor activity of 9-anilinoacridine derivatives. In agreement with these studies, this class of compounds, possessing a variety of small nonpolar groups at the 3-position, together with very hydrophilic carboxamido groups at the 5-position, have high in vivo activity against animal leukemia models.