6333-29-5

Basic information

• Product Name: 2,6-bis(morpholin-4-ylmethyl)cyclohexanone
• CAS NO: 6333-29-5
• Molecular Formula: C₁₆H₂₈N₂O₃*2ClH
• Molecular Weight: 296.4051
• Mol File: 6333-29-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 426.5°C at 760 mmHg
• Flash Point: 211.7°C
• Density: 1.108g/cm³
• Vapor Pressure: 1.76E-07mmHg at 25°C
• Refractive Index: 1.513
• CAS DataBase Reference: 2,6-bis(morpholin-4-ylmethyl)cyclohexanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-bis(morpholin-4-ylmethyl)cyclohexanone(6333-29-5)
• EPA Substance Registry System: 2,6-bis(morpholin-4-ylmethyl)cyclohexanone(6333-29-5)

Safety Data

• Hazardous Substances Data: 6333-29-5(Hazardous Substances Data)

Usage

General Description

2,6-bis(morpholin-4-ylmethyl)cyclohexanone, also known as BMK, is a key intermediate used in the illegal production of methamphetamine. It is a white, crystalline solid with a chemical formula of C16H28N2O2. BMK is a precursor chemical that is converted into the final product, methamphetamine, through a series of chemical reactions. Due to its role in the production of illicit drugs, BMK is a controlled substance in many countries and its sale, purchase, or possession is illegal without proper authorization. Law enforcement agencies closely monitor the production and distribution of BMK in an effort to combat the illegal drug trade.

Upstream product

• 50-00-0 formaldehyd 
• 10024-89-2 morpholin hydrochloride 
• 108-94-1 cyclohexanone 

Relevant articles and documents

Evaluation of some Mannich bases of cycloalkanones and related compounds for cytotoxic activity

A number of Mannich bases of cycloalkanones and related quaternary ammonium compounds were prepared for cytotoxic evaluation in order to examine the theory that sequential release of alkylating agents produces increased bioactivity compared to related compounds containing only 1 potential alkylating site.Many of the compounds had significant activity against murine L1210 cells and various human tumours.Some correlations between structure and activity were noted but the biological data did not support the view that potential sequential liberation of cytotoxic species produced compounds with increased potency.The formation of various oximes and oxime benzoates as candidate prodrugs was achieved but in general these compounds were not cytotoxic at the concentrations utilized.This observation may be due to the fact that the oximes were much more stable in deuterated phosphate buffered saline over a period of 48 h at 37 deg than the Mannich bases, as revealed by 1H-NMR spectroscopy. Mannich bases / cytotoxic evaluations / prodrugs / 1H-NMR spectroscopy / structure-activity relationships