633328-98-0

Basic information

• Product Name: 1H-Pyrazolo[4,3-d]pyriMidine, 5-chloro-
• Synonyms: 1H-Pyrazolo[4,3-d]pyriMidine, 5-chloro-;5-CHLORO-1H-PYRAZOLO[4,3-D]PYRIMIDINE
• CAS NO: 633328-98-0
• Molecular Formula: C5H3ClN4
• Molecular Weight: 154.55712
• Mol File: 633328-98-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.653±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 6.68±0.50(Predicted)
• CAS DataBase Reference: 1H-Pyrazolo[4,3-d]pyriMidine, 5-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazolo[4,3-d]pyriMidine, 5-chloro-(633328-98-0)
• EPA Substance Registry System: 1H-Pyrazolo[4,3-d]pyriMidine, 5-chloro-(633328-98-0)

Safety Data

• Hazardous Substances Data: 633328-98-0(Hazardous Substances Data)

Usage

Description

1H-Pyrazolo[4,3-d]pyrimidine, 5-chlorois a chemical compound belonging to the pyrazolopyrimidine class. It is characterized by the presence of a pyrazole and a pyrimidine ring fused together, with a chlorine atom at the 5-position. 1H-Pyrazolo[4,3-d]pyrimidine, 5-chloroserves as a key intermediate in the synthesis of various pyrimidine derivatives and related heterocycles.

Uses

Used in Pharmaceutical Industry:
1H-Pyrazolo[4,3-d]pyrimidine, 5-chlorois used as a precursor in the synthesis of pyrimidine derivatives and related heterocycles. These synthesized compounds act as DNA-dependent protein kinase (DNA-PK) inhibitors, which have potential applications in the treatment of various diseases. By inhibiting DNA-PK, these pyrimidine derivatives can interfere with the repair of DNA damage, making them useful in targeting cancer cells and other disease-causing agents.

InChI:InChI=1S/C5H3ClN4/c6-5-7-1-4-3(9-5)2-8-10-4/h1-2H,(H,8,10)

Upstream product

• 13162-27-1 5-amino-2,4-dichloro-6-methylpyrimidine 
• 13162-26-0 2,4-dichloro-6-methyl-5-nitropyrimidine 
• 16632-21-6 5-nitro-6-methyluracil 
• 626-48-2 6-Methyluracil 
• 633328-97-9 1-{5-chloro-1H-pyrazolo[4,3-d]pyrimidin-1-yl}ethan-1-one 
• 20090-69-1 2-chloro-4-methyl-5-aminopyrimidine 
• 633328-96-8 N-(2-chloro-4-methylpyrimidin-5-yl)acetamide 

Downstream Products

• 1393181-01-5 5-chloro-1-methyl-1H-pyrazolo[4,3-d]pyrimidine 

Relevant articles and documents

Biochemical, cellular and structural characterization of novel and selective ERK3 inhibitors

Triazolo[4,5-d]pyrimidin-5-amines were identified from kinase selectivity screening as novel ERK3 inhibitors with sub-100 nanomolar potencies in a biochemical assay using MK5 as substrate and with an attractive kinase selectivity profile. ERK3 crystal structures clarified the inhibitor binding mode in the ATP pocket with impact on A-loop, GC-loop and αC-helix conformations suggesting a potential structural link towards MK5 interaction via the FHIEDE motif. The inhibitors also showed sub-100 nM potencies in a cellular ERK3 NanoBRET assay and with excellent correlation to the biochemical IC50s. This novel series provides valuable tool compounds to further investigate the biological function and activation mechanism of ERK3.

Ethanol compound used as FGFR inhibitor

The invention discloses an ethanol compound used as a FGFR inhibitor. The invention provides the compound as shown in a formula I which is described in the specification or a pharmaceutically acceptable salt thereof, a preparation method for the compound and application of the compound as a medicine to treatment of cancers.