6336-42-1Relevant articles and documents
Regioselective alkylation reaction of purines under microwave irradiation
Ginard, Jaume,Jahani, Daniel,Mur, Nuria,Pujol, Maria Dolors,Vi?as, Miquel,Vinuesa, Arturo
, (2021/12/22)
The alkylation of purines which is generally carried out after anion formation by treatment with a base and alkyl halide is complicated and in the best cases, mixtures of N-alkylated compounds are obtained. Purine derivatives can be acquired from alkylati
Exploring metal ion coordination and ring expansion chemistry of modified purine derivatives
Avasthi, Ilesha,Mamtani, Himanshu,Khanna, Shruti,Verma, Sandeep
, p. 73 - 82 (2018/09/14)
Well-defined coordinating behavior and binding properties of nucleobases with metal ions result in intriguing supramolecular architectures and multidimensional useful coordination polymers. These naturally occurring heterocyclic moieties serve as a versatile tool for the development of interesting potential frameworks for desired applications. We present four complexes of transition metals (Hg, Ag, and Zn) derived from N9-modified 6-chloropurine and 2-amino-6-chloropurine. N9 derivatization involves exploring the influence of aliphatic, aromatic, and heteroaromatic substituents on the coordination behavior of the metals with purines. We also observed an interesting transformation where one complex supported Hg(II)-mediated cyclization followed by the formation of an organomercury adduct.
Di-p-nitrobenzyl azodicarboxylate (DNAD): An alternative azo-reagent for the Mitsunobu reaction
Yang, Jianhai,Dai, Liyan,Wang, Xiaozhong,Chen, Yingqi
experimental part, p. 1456 - 1462 (2011/03/21)
Di-p-nitrobenzyl azodicarboxylate is prepared in 83.6% yield in two steps as a bright yellow solid, which can be used as an azo-reagent in the Mitsunobu reaction. When a chiral secondary alcohol was used, sufficient configurational inversion of alcohol occurred under Mitsunobu conditions. That the hydrazine produced from DNAD is semisoluble in some solvents such as THF and CH 2Cl2 makes it separated easily from the reaction mixture just via filtration. Then the recovered hydrazine compound can be re-exposed to oxidant to produce DNAD. Because DNAD is more stable than DIAD at ambient temperatures and allows easy separation, it is a good alternative azo-reagent for the Mitsunobu reaction.