63362-42-5Relevant articles and documents
Preparation of highly functionalized pyridylmagnesium reagents for the synthesis of polyfunctional pyridines
Bérillon, Laurent,Leprêtre, Anne,Turck, Alain,Plé, Nelly,Quéguiner, Guy,Cahiez, Gérard,Knochel, Paul
, p. 1359 - 1360 (1998)
Functionalized iodopyridines bearing either a chloride, ester or nitrile function were converted to the corresponding organomagnesium derivatives at -40°C or -78°C by treatment with i-PrMgBr (1.1 equiv, 0.5 h, > 90% yield). The resulting functionalized Grignard reagents react with aldehydes, TosCN directly or with allylic bromides and benzoyl chloride after transmetalation with CuCN leading to polyfunctional pyridines.