63368-36-5

Basic information

• Product Name: (2-METHYLBENZYL)TRIPHENYLPHOSPHONIUM CHLORIDE
• Synonyms: [(2-methylphenyl)methyl]triphenyl-phosphoniuchloride;[(2-METHYLPHENYL)METHYL]-TRIPHENYLPHOSPHONIUM CHLORIDE;(2-METHYLBENZYL)TRIPHENYLPHOSPHONIUM CHLORIDE;2-Methylbenzyl triphenylphosphonium chloride, 98+%;2-Methylbenzyltriphenylphosphonium chloride,99%;(2-methylphenyl)methyl-triphenylphosphanium,chloride
• CAS NO: 63368-36-5
• Molecular Formula: C₂₆H₂₄P*Cl
• Molecular Weight: 402.9
• EINECS: 264-112-3
• Mol File: 63368-36-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 275-277 °C
• Appearance: /solid
• Sensitive: Hygroscopic
• BRN: 4172676
• CAS DataBase Reference: (2-METHYLBENZYL)TRIPHENYLPHOSPHONIUM CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (2-METHYLBENZYL)TRIPHENYLPHOSPHONIUM CHLORIDE(63368-36-5)
• EPA Substance Registry System: (2-METHYLBENZYL)TRIPHENYLPHOSPHONIUM CHLORIDE(63368-36-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26
• TSCA: Yes
• Hazardous Substances Data: 63368-36-5(Hazardous Substances Data)

Usage

Chemical Properties

WHITE CRYSTALLINE POWDER

InChI:InChI=1/C26H24P.ClH/c1-22-13-11-12-14-23(22)21-27(24-15-5-2-6-16-24,25-17-7-3-8-18-25)26-19-9-4-10-20-26;/h2-20H,21H2,1H3;1H/q+1;/p-1

Upstream product

• 603-35-0 triphenylphosphine 
• 89-92-9 2-methylbenzyl bromide 
• 552-45-4 1-chloromethyl-2-methylbenzene 

Downstream Products

• 952-80-7 1,2-bis(2-methylphenyl)ethane 
• 66107-08-2 1-(2-nitrostyryl)-2-methylbenzene 
• 14320-04-8 zinc(II) phthalocyanine 
• 1586046-62-9 27-(2-methylphenyl)tetrabenzo[b,g,l,q][5,10,15]triazaporphyrinato zinc 
• 1375501-11-3 1-benzoyl-3-[4-(2-o-tolyl-ethyl)-pyridin-2-yl]-urea 
• 1340333-96-1 4-(2-o-tolyl-ethyl)-pyridin-2-ylamine 
• 1375501-06-6 4-(2-o-tolyl-vinyl)-pyridin-2-ylamine 
• 1375500-04-1 [4-(2-o-tolyl-ethyl)-pyridin-2-yl]-urea 
• 1375501-03-3 2-bromo-4-(2-o-tolyl-vinyl)-pyridine 
• 1313222-03-5 C₂₀H₃₂N₂O₄S 
• 1313221-45-2 C₂₁H₃₂N₂O₅S 
• 1313221-89-4 C₂₀H₂₉NO₃S 
• 1313221-81-6 C₁₅H₂₃NO₂S 
• 1313221-68-9 C₁₅H₂₁NO₂S 

Relevant articles and documents

Reactions of benzyltriphenylphosphonium salts under photoredox catalysis

The development of benzyltriphenylphosphonium salts as alkyl radical precursors using photoredox catalysis is described. Depending on substituents, the benzylic radicals may couple to form C-C bonds or abstract a hydrogen atom to form C-H bonds. A natural product, brittonin A, was also synthesized using this method.

Styrylphenylphthalimides as Novel Transrepression-Selective Liver X Receptor (LXR) Modulators

Anti-inflammatory effects of liver X receptor (LXR) ligands are thought to be largely due to LXR-mediated transrepression, whereas side effects are caused by activation of LXR-responsive gene expression (transactivation). Therefore, selective LXR modulators that preferentially exhibit transrepression activity should exhibit anti-inflammatory properties with fewer side effects. Here, we synthesized a series of styrylphenylphthalimide analogues and evaluated their structure-activity relationships focusing on LXRs-transactivating-agonistic/antagonistic activities and transrepressional activity. Among the compounds examined, 17l showed potent LXR-transrepressional activity with high selectivity over transactivating activity and did not show characteristic side effects of LXR-transactivating agonists in cells. This representative compound, 17l, was confirmed to have LXR-dependent transrepressional activity and to bind directly to LXRβ. Compound 17l should be useful not only as a chemical tool for studying the biological functions of LXRs transrepression but also as a candidate for a safer agent to treat inflammatory diseases.

Aluminium triflate catalysed cyclisation of unsaturated alcohols: novel synthesis of rose oxide and analogues

Aluminium trifluoromethanesulfonate was used as an efficient catalyst for the cycloisomerisation of several unsaturated alcohols into cyclic ethers such as rose oxide and some of its ether analogues.