63379-16-8

Basic information

• Product Name: Carbamic acid, (4-methylphenyl)-, propyl ester
• CAS NO: 63379-16-8
• Molecular Formula: C11H15NO2
• Molecular Weight: 193.246
• Mol File: 63379-16-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Carbamic acid, (4-methylphenyl)-, propyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (4-methylphenyl)-, propyl ester(63379-16-8)
• EPA Substance Registry System: Carbamic acid, (4-methylphenyl)-, propyl ester(63379-16-8)

Safety Data

• Hazardous Substances Data: 63379-16-8(Hazardous Substances Data)

Upstream product

• 71-23-8 propan-1-ol 
• 622-58-2 p-Tolylisocyanate 
• 124-38-9 carbon dioxide 
• 106-49-0 p-toluidine 
• 106-94-5 propyl bromide 
• 540-54-5 1-Chloropropane 
• 590-28-3 potassium cyanate 
• 1177-35-1 2,4,6-Tris(4-methylphenoxy)-1,3,5-triazine 
• 627-12-3 1-propyl carbamate 
• 106-38-7 para-bromotoluene 
• 624-31-7 4-tolyl iodide 
• 201230-82-2 carbon monoxide 
• 621-00-1 1,3-di-p-tolylurea 
• 5720-05-8 4-methylphenylboronic acid 

Downstream Products

• 73262-67-6 2-Amino-5-methyl-benzoic acid propyl ester 
• 106-49-0 p-toluidine 

Relevant articles and documents

Nickel-Catalyzed Synthesis of N-(Hetero)aryl Carbamates from Cyanate Salts and Phenols Activated with Cyanuric Chloride

A simple and efficient domino reaction has been designed and employed for the one-pot synthesis of N-(hetero)aryl carbamates through the reaction between alcohols and in-situ produced (hetero)aryl isocyanates in the presence of a nickel catalyst. The phenolic C?O bond was activated via the reaction of phenol with cyanuric chloride (2,4,6-trichloro-1,3,5-triazine (TCT)) as an inexpensive and readily available reagent. This strategy provides practical access to N-(hetero)aryl carbamates in good yields with high functional groups compatibility.

A Fe3O4?SiO2/Schiff Base/Pd Complex as an Efficient Heterogeneous and Recyclable Nanocatalyst for One-Pot Domino Synthesis of Carbamates and Unsymmetrical Ureas

A palladium-catalyzed domino method for the direct synthesis of carbamates and ureas has been developed by using readily available and economical starting materials (aryl halide, carbon monoxide, sodium azide, amines and alcohols) in a one-pot approach. The domino process underwent carbonylation, Curtius rearrangement, and nucleophilic addition. This protocol provides a step-economical and highly efficient reaction to access the wide range of valuable carbamates, symmetrical and unsymmetrical ureas with high yields under remarkable mild reaction conditions that are important factors in pharmaceutical science, biochemistry and agricultural industries. Furthermore, the magnetically recoverable nanocatalyst (Fe3O4?SiO2/Pd(II)) can be conveniently and swiftly recycled using external magnet and reused at least for seven times without noticeable loss of its catalytic activity.

Ureas as safe carbonyl sources for the synthesis of carbamates with deep eutectic solvents (DESs) as efficient and recyclable solvent/catalyst systems

A simple, efficient and eco-friendly one-pot synthesis of primary, N-mono- and N-disubstituted carbamates is developed from ureas. The corresponding carbamates were produced at 120 °C, within 18 h, and in the presence of a deep eutectic solvent as a recyclable catalytic system. The catalyst can be reused for several runs without any reduction in its activity. To demonstrate the utility of this approach, a wide variety of alcohols and phenols were studied to find a vast range of carbamate derivatives in moderate to high yields.