63399-77-9 Usage
Description
H-ALPHA-ME-D-PRO-OH, also known as (R)-2-Methyl Proline, is a derivative of D-Proline (P755990). It is an amino acid that plays a crucial role in the synthesis of various compounds and has potential applications in different industries.
Uses
Used in Pharmaceutical Industry:
H-ALPHA-ME-D-PRO-OH is used as a building block for the synthesis of various pharmaceutical compounds, such as (R)-(+)-N-Boc-Pipecolic Acid, (S)-(-)-Coniine, (S)-(+)-Pelletierine, (+)-.beta.-Conhydrine, and (S)-(-)-Ropivacaine. It is also used in the formal synthesis of (-)-Lasubine II and (+)-Cermizine C. The presence of this amino acid in the synthesis process contributes to the development of new drugs and therapeutic agents.
Used in Chemical Synthesis:
H-ALPHA-ME-D-PRO-OH is used as a key intermediate in the chemical synthesis of various organic compounds. Its unique structure allows for the creation of complex molecules that can be utilized in a wide range of applications, from pharmaceuticals to materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 63399-77-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,3,9 and 9 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 63399-77:
(7*6)+(6*3)+(5*3)+(4*9)+(3*9)+(2*7)+(1*7)=159
159 % 10 = 9
So 63399-77-9 is a valid CAS Registry Number.
InChI:InChI:1S/C6H11NO2/c1-6(5(8)9)3-2-4-7-6/h7H,2-4H2,1H3,(H,8,9)
63399-77-9Relevant articles and documents
Α-substd. provitamin optically active production of phosphorus
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, (2016/12/26)
PROBLEM TO BE SOLVED: To provide an industrial method practically suitable for producing an optically active α-substituted prolines with short process and mild conditions.SOLUTION: A method of producing an optically active α-substituted prolines (6) includes (d) a step of obtaining an optically active N, α-substituted prolines (5) by hydrolysis of an optically active N, α-substituted proline amides (4), and (e) a step of obtaining an optically active α-substituted prolines (6) by eliminating the optically active N, and a protective group Rof the α-substituted prolines (5).
Is the backbone conformation of Cα-methyl proline restricted to a single region?
De Poli, Matteo,Moretto, Alessandro,Crisma, Marco,Peggion, Cristina,Formaggio, Fernando,Kaptein, Bernard,Broxterman, Quirinus B.,Toniolo, Claudio
experimental part, p. 8015 - 8025 (2010/03/31)
Cα-Methyl-L-proline, or L(αMe)Pro, is probably the most conformational constrained α-amino acid. In particular, its ω and o torsion angles are restricted to about 180 and -60°, respectively, and only three ranges of values are theoretically ava