6340-16-5

Basic information

• Product Name: Carbonothioicdihydrazide, 2,2'-bis[(4-chlorophenyl)methylene]-
• Synonyms: Benzaldehyde,p-chloro-, thiocarbohydrazone (8CI); Carbonothioic dihydrazide, bis[(4-chlorophenyl)methylene]-(9CI); NSC 51366
• CAS NO: 6340-16-5
• Molecular Formula: C15H12 Cl2 N4 S
• Molecular Weight: 351.259
• Mol File: 6340-16-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 473.6°Cat760mmHg
• Flash Point: 240.2°C
• Density: 1.33g/cm³
• CAS DataBase Reference: Carbonothioicdihydrazide, 2,2'-bis[(4-chlorophenyl)methylene]-(CAS DataBase Reference)
• NIST Chemistry Reference: Carbonothioicdihydrazide, 2,2'-bis[(4-chlorophenyl)methylene]-(6340-16-5)
• EPA Substance Registry System: Carbonothioicdihydrazide, 2,2'-bis[(4-chlorophenyl)methylene]-(6340-16-5)

Safety Data

• Hazardous Substances Data: 6340-16-5(Hazardous Substances Data)

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 2231-57-4 Thiocarbohydrazide 

Downstream Products

• 1412457-78-3 (Z)-methyl 2-[(Z)-3-((E)-(4-chlorobenzylidene)amino)-2-((E)-(4-chlorobenzylidene)hydrazono)-4-oxothiazolidin-5-ylidene]acetate 
• 144139-99-1 4-(4-chloro-benzylideneamino)-5-(4-chlorophenyl)-2H-1,2,4-triazole-3(4H)-thione 
• 119023-47-1 N¹,N⁵-di(2-p-chlorophenyl-4-oxothiazolidin-3-yl)thiourea 

Relevant articles and documents

Design and synthesis of new thiazoles by microwave-assisted method: Evaluation as an anti-breast cancer agents and molecular docking studies

A series of novel thiazole analogues were designed and synthesized by the microwave-assisted multicomponent reaction of thiocarbohydrazide, aldehydes with substituted phenacyl bromides. Structures of all the synthesized compounds were in good agreement with their spectral (1H and 13C NMR, FTIR, Mass) and analytical data. The target thiazole compounds were screened for their in?vitro cytotoxic activity by testing against MCF-7, MDA-MB-231/ATCC, HS 578 T, BT-549, T-47D and MDA-MB-468 Breast cancer cell lines. From the in?vitro results, it was found that the compound 4b has potent activity against MDA-MB-231/ATCC cell line. Docking studies were also done on these compounds to probe the possible binding site interactions which corroborated well with the in?vitro results.

Synthesis of novel triazoles, tetrazine, thiadiazoles and their biological activities

An expedient synthesis of novel triazoles, tetrazine and thiadiazoles, using conveniently accessible and commercially available starting materials has been achieved. The synthesized compounds were characterized by spectroscopic and elemental analyses, and screened for their antibacterial activities against four different strains, namely E. coli, P. aeruginosa, S. aureus and B. megaterium. In particular, the compounds 5, 24 and 26h exhibited excellent antibacterial activities compared to the reference antibiotic. To get further insight about their behavior, these compounds were tested for their antioxidant activities via SOD-like activity, DPPH free radical scavenging activity, ABST and NO, which showed promising results. Furthermore, these compounds effectively promoted the cleavage of genomic DNA as well, in the absence of any external additives.

Synthesis and Characterization of Bis-thiocarbonohydrazones

Several bis-thiocarbonohydrazones have been synthesized using improved methods.The compounds prepared have been characterized by elemental analyses, melting points, and IR and PMR spectra.