6340-72-3

Basic information

• Product Name: 2-amino-6-phenyl-5,6-dihydropyrimidin-4(3H)-one
• Synonyms: 2-Amino-6-phenyl-5,6-dihydropyrimidin-4(3H)-one; 4(3H)-Pyrimidinone, 2-amino-5,6-dihydro-6-phenyl-
• CAS NO: 6340-72-3
• Molecular Formula: C₁₀H₁₁N₃O
• Molecular Weight: 189.2138
• Mol File: 6340-72-3.mol
• Article Data: 6

Chemical Properties

• Density: 1.35g/cm³
• Refractive Index: 1.671
• CAS DataBase Reference: 2-amino-6-phenyl-5,6-dihydropyrimidin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-6-phenyl-5,6-dihydropyrimidin-4(3H)-one(6340-72-3)
• EPA Substance Registry System: 2-amino-6-phenyl-5,6-dihydropyrimidin-4(3H)-one(6340-72-3)

Safety Data

• Hazardous Substances Data: 6340-72-3(Hazardous Substances Data)

Usage

Chemical Class

Dihydropyrimidines

Medical Use

Anticonvulsant medication

Mode of Action

Stabilizes nerve cell membranes, reduces excessive electrical activity in the brain

Applications

Controls seizures in individuals with epilepsy
Studied for potential use in treating neuropathic pain
Investigated as a neuroprotective agent

Safety Profile

Favorable

Tolerability

Generally well-tolerated

Common Prescription

For management of epilepsy and related conditions

Upstream product

• 113-00-8 guanidine nitrate 
• 125231-39-2 3-phenyl-1-[2,3,5,6-tetrafluoro-4-(piperidin-1-yl)phenyl]prop-2-en-1-one 
• 50-01-1 guanidine hydrochloride 
• 54081-33-3 trans-styryl(2',3',4',5',6'-pentafluorophenyl)ketone 
• 2033-24-1 cycl-isopropylidene malonate 
• 506-93-4 guanidine nitrate 
• 100-52-7 benzaldehyde 
• 593-85-1 diguanidine carbonate 
• 124-46-9 guanidine hydrogen carbonate 
• 3646-50-2 3-Amino-3-phenylpropionic acid 
• 4192-77-2 ethyl cinnamate 
• 64-17-5 ethanol 
• 103-26-4 Methyl cinnamate 
• 1885-38-7 cinnamic nitrile 

Downstream Products

• 13345-09-0 6-phenyluracil 

Relevant articles and documents

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Reaction of polyfluorinated chalcones with guanidine

Reactions of polyfluorinated chalcones with guanidine in the presence of bases are accompanied by elimination of the polyfluorophenyl group. 3-(Pentafluorophenyl)-1-phenylprop-2-en-1-one and its derivatives reacted with guanidine under basic conditions to give 4-phenylpyrimidin-2-amine, polyfluorobenzenes, and Michael adducts, 3-(2-amino-4-phenylpyrimidin-5-yl)-3-(4-R-2,3,5,6-tetrafluorophenyl)-1-phenylpropan-1-ones. 1-(Pentafluorophenyl)-3-phenylprop-2-en-1-one and 1,3-bis(pentafluorophenyl)prop-2-en-1-one were converted into cinnamic acid derivatives whose reaction with guanidine afforded 2-amino-6-aryl-5,6-dihydropyrimidin-4(1H)-ones.

Efficient synthesis of 2-amino-6-aryl-5,6-dihydro -3#-pyrimidin-4-one building blocks via domino reaction

One-pot three component condensation of Meldrum's acid, benzaldehyde derivatives and guanidinium carbonate leads to 2-amino-6-aryl-5,6-dihydro-3H- pyrimidin-4-one derivatives in good yields. The products can be utilized in the synthesis of diverse heterocyclic compounds libraries.