63409-02-9

Basic information

• Product Name: 3-Methylnaphthalene-1-carboxaldehyde
• Synonyms: 3-Methylnaphthalene-1-carboxaldehyde;3-Methyl-naphthalene-1-carbaldehyde
• CAS NO: 63409-02-9
• Molecular Formula: C₁₂H₁₀O
• Molecular Weight: 170.2072
• Mol File: 63409-02-9.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Methylnaphthalene-1-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methylnaphthalene-1-carboxaldehyde(63409-02-9)
• EPA Substance Registry System: 3-Methylnaphthalene-1-carboxaldehyde(63409-02-9)

Safety Data

• Hazardous Substances Data: 63409-02-9(Hazardous Substances Data)

Upstream product

• 91388-35-1 1-formyl-2-(2,2-dimethylethenyl)benzene 
• 1413394-06-5 2,2-dichloro-1-[2-(2-methylprop-1-en-1-yl)phenyl]ethanone 
• 38552-83-9 1-[2-(2-methylprop-1-en-1-yl)phenyl]ethanone 
• 33107-14-1 2-(2,4-dinitrophenyl)-isoquinolinium chloride 
• 575-41-7 1,3-dimethylnaphthalene 
• 64-19-7 acetic acid 

Relevant articles and documents

Substituents at the naphthalene C3 position of (-)-Cercosporamide derivatives significantly affect the maximal efficacy as PPARγ partial agonists

Peroxisome proliferator-activated receptor gamma (PPARγ) is a potential drug target for treating type 2 diabetes. The selective PPARγ modulators (SPPARMs), which partially activate the PPARγ transcriptional activity, are considered to improve the plasma glucose level with attenuated PPARγ related adverse effects. However, the relationships between desired pharmacological profiles and ligand specific PPARγ transcriptional profiles have been unclear. And there is also little knowledge of how to control ligand specific PPARγ transcriptional profiles. Herein, we present synthesis of novel derivatives containing substituent at naphthalene C3 position of compound 1. The novel derivatives showed various maximal efficacies as PPARγ partial agonist.

Palladium-Catalyzed Regiospecific peri- And ortho-C-H Oxygenations of Polyaromatic Rings Mediated by Tunable Directing Groups

An efficient divergent approach of Pd-catalyzed C-H oxygenation of polyaromatic rings is described. Reversible directing groups enable regiospecific peri- and ortho-oxygenation to readily access a wide array of polyaromatic phenols without pre- and postmanipulation of directing groups. The systematic mechanistic investigation, including deuterium-labeling experiments, palladacycle trapping, and DFT calculations, reveals that the tunable ligand-assisted C-H bond cleavage played a crucial role during the reaction process.

Cyclization of (2-alkenylphenyl)carbonyl compounds to polycyclic arenes catalyzed by copper(II) trifluoromethanesulfonate or trifluoromethanesulfuric acid

Various polycyclic arenes, such as naphthalenes, tetrahydroantharacenes, tetrahydrotetracenes, dihydropentacenes, and dihydropentaphenes are prepared from 2-alkenylphenyl ketones and aldehydes by the catalytic use of copper(II) trifluoromethanesulfonate (Cu(OTf)2) or trifluoromethanesulfuric acid (TfOH). Copyright