63480-10-4

Basic information

• Product Name: 4-NITRO-ISATOIC ANHYDRIDE
• Synonyms: 7-NITRO-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE;4-NITRO-ISATOIC ANHYDRIDE;4-Nitroisatoic anhydride 97%;7-Nitro-2H-3,1-benzoxazine-2,4(1H)-dione, 7-Nitro-1H-benzo[d][1,3]oxazine-2,4-dione;NSC 135175;7-nitro-1H-3,1-benzoxazine-2,4-dion;4-Nitroisatoicanhydride97%;2H-3,1-Benzoxazine-2,4(1H)-dione, 7-nitro-
• CAS NO: 63480-10-4
• Molecular Formula: C₈H₄N₂O₅
• Molecular Weight: 208.13
• Mol File: 63480-10-4.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• Density: 1.623 g/cm³
• Refractive Index: 1.629
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-NITRO-ISATOIC ANHYDRIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-NITRO-ISATOIC ANHYDRIDE(63480-10-4)
• EPA Substance Registry System: 4-NITRO-ISATOIC ANHYDRIDE(63480-10-4)

Safety Data

• Hazardous Substances Data: 63480-10-4(Hazardous Substances Data)

Usage

General Description

4-NITRO-ISATOIC ANHYDRIDE is a chemical compound with the molecular formula C8H3N3O5. It is a yellow crystalline solid that is used as an intermediate in the synthesis of pharmaceuticals, dyes, and other organic compounds. It is a nitro derivative of isatoic anhydride and is known for its strong electron-withdrawing properties, making it useful in organic reactions such as nitration, halogenation, and Friedel-Crafts acylation. It is also used as a reagent in the preparation of various heterocyclic compounds and as an efficient catalyst in various organic transformations. This chemical has potential applications in the pharmaceutical and chemical industries due to its versatile reactivity and unique structural properties.

InChI:InChI=1/C8H4N2O5/c11-7-5-2-1-4(10(13)14)3-6(5)9-8(12)15-7/h1-3H,(H,9,12)

Upstream product

• 619-17-0 4-Nitroanthranilic acid 
• 530-62-1 1,1'-carbonyldiimidazole 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 219491-92-6 2-amino-N-(4-methoxyphenyl)-4-nitrobenzamide 
• 791098-03-8 1-(2-amino-4-nitrobenzoyl)piperidine 
• 1254069-38-9 3-(methylthio)-1-phenyl-1H-indazol-6-amine 
• 1254069-41-4 4-(3-methylsulfanyl-1-phenyl-1H-indazol-6-ylcarbamoyl)piperidine-1-carboxylicacid tert-butyl ester 
• 1254069-36-7 N-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)piperidine-4-carboxamide hydrochloride 
• 1254069-39-0 6-nitro-1-phenyl-2,3-dihydro-1H-indazol-3-one 
• 67571-10-2 2-amino-4-nitro-N'-phenylbenzohydrazide 
• 49565-62-0 2-(methylamino)-4-nitro-benzoic acid 
• 31930-18-4 2-amino-4-nitrobenzamide 
• 1520077-97-7 2-amino-N-methoxy-4-nitrobenzamide 
• 1520078-16-3 3-methoxy-7-nitro-2-phenylquinazolin-4(3H)-one 
• 1345404-93-4 3-methoxy-1-phenyl-1H-indazol-6-ylamine 
• 1345404-92-3 3-methoxy-6-nitro-1-phenyl-1H-indazole 
• 1345404-02-5 3-[3-(3-Methylsulfanyl-1-phenyl-1H-indazol-6-yl)-ureido]-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

New spiro pyrrole[2, 1-b]quinazolone derivative, preparation method and application thereof

The invention relates to a new spiro pyrrole[2, 1-b]quinazolone derivative, a preparation method and application thereof. The new spiro pyrrole[2, 1-b]quinazolone derivative is synthesized by using asimple method. The yield is high, the production cost is

Amino evodiamine derivative and preparation method and application thereof

The invention discloses an amino evodiamine derivative and a preparation method and application thereof. A carboline compound and N-methyl-7-nitro isatoic anhydride are used for preparing a 2-nitro evodiamine derivative, and the 2-nitro evodiamine derivative is reduced to obtain the amino evodiamine derivative. A cytotoxicity experiment is performed by using a CCK-8 method, the anti-proliferationeffect of the compound on breast cancer MDA-MB-231 cells, colon cancer SW620 cells and normal liver LO2 cells is evaluated, and cell apoptosis detection is performed by using FITC/PI double staining;experiments show that compared with evodiamine, the compound 2-NH2-EVO has a very strong inhibition effect on breast cancer cells MDA-MB-231, the IC50 value is 0.79 uM, meanwhile, cell apoptosis can be remarkably induced, and the compound 2-NH2-EVO is expected to be developed into an anti-cancer drug with potential.

Doxorubicin-loaded polymeric micelle as well as preparation method and application thereof

The present invention discloses a doxorubicin-loaded polymeric micelle as well as a preparation method and application thereof. Novel amino evodiamine is adopted to react with polyethylene glycol, a micelle obtained by self-assembly is used as a carrier to load doxorubicin, a prepared mPEG-CO-NH-EVO micelle and a mPEG-CO-NH-EVO-OCH3 micelle have low toxicity to normal hepatocytes so that the two amphipathic polymeric micelles are used as carriers to load DOX to prepare DOX-loaded polymeric micelles, namely a mPEG-CO-NH-EVO/DOX micelle and a mPEG-CO-NH-EVO-OCH3/DOX micelle, and DOX enters hydrophobic shells of the micelles due to the dialysis effect; shapes of the micelles are represented by using a transmission electron microscope and a scanning electron microscope, and the drug loading efficiency and encapsulation efficiency of DOX are tested and calculated by using an ultraviolet spectrophotometer; and finally, evaluating the cytotoxicity by using a CCK-8 method. Shown by cytotoxicity tests, a DOX-loaded polymer has an effect on inhibiting breast cancer cells and particularly has greatly reduced toxicity to the normal hepatocytes.