635-27-8

Basic information

• Product Name: 5-CHLOROQUINOLINE
• Synonyms: 5-CHLOROQUINOLINE;5-Chloroquinoline hydrochloride
• CAS NO: 635-27-8
• Molecular Formula: C₉H₆ClN
• Molecular Weight: 163.6
• EINECS: -0
• Product Categories: Aromatics;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Quinolines;QuinolinesHeterocyclic Building Blocks
• Mol File: 635-27-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: 28-32 °C
• Boiling Point: 263°C(lit.)
• Flash Point: 145.2°C
• Appearance: /
• Density: 1.2108 (rough estimate)
• Vapor Pressure: 0.0098mmHg at 25°C
• Refractive Index: 1.6110 (estimate)
• Storage Temp.: 2-8°C
• Solubility: Chloroform, Ethyl Acetate, Methanol
• PKA: 3.88±0.12(Predicted)
• BRN: 114722
• CAS DataBase Reference: 5-CHLOROQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLOROQUINOLINE(635-27-8)
• EPA Substance Registry System: 5-CHLOROQUINOLINE(635-27-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 635-27-8(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

5-Chloroquinoline (cas# 635-27-8) is a compound useful in organic synthesis.

InChI:InChI=1/C9H6ClN/c10-8-4-1-5-9-7(8)3-2-6-11-9/h1-6H

Upstream product

• 108-42-9 3-chloro-aniline 
• 56-81-5 glycerol 
• 504-63-2 trimethyleneglycol 
• 578-67-6 quinolin-5-ol 
• 611-34-7 5-Aminoquinoline 
• 124-40-3 dimethyl amine 

Downstream Products

• 1174987-67-7 Br^(1-)*C₁₇H₁₂ClN₂O₃⁽¹⁺⁾ 
• 1174987-69-9 Br^(1-)*C₁₈H₁₅ClNO₂⁽¹⁺⁾ 
• 713077-24-8 5-chloro-1-phenacyl-quinolinium bromide 
• 1174987-68-8 Br^(1-)*C₁₇H₁₂ClN₂O₃⁽¹⁺⁾ 
• 713077-32-8 5-Chloro-1-[2-(4-fluoro-phenyl)-2-oxo-ethyl]-quinolinium bromide 
• 511231-69-9 1-Benzoyl-5-chloro-2-cyano-1,2-dihydroquinoline 
• 72995-16-5 5-chloro-1,2,3,4-tetrahydroquinoline 
• 59412-12-3 2,5-dichloroquinoline 
• 90225-09-5 5-chloro-quinoline-8-sulfonic acid 
• 91-22-5 quinoline 

Relevant articles and documents

Discovery of an Inhibitor of the Proteasome Subunit Rpn11

The proteasome plays a crucial role in degradation of normal proteins that happen to be constitutively or inducibly unstable, and in this capacity it plays a regulatory role. Additionally, it degrades abnormal/damaged/mutant/misfolded proteins, which serves a quality-control function. Inhibitors of the proteasome have been validated in the treatment of multiple myeloma, with several FDA-approved therapeutics. Rpn11 is a Zn2+-dependent metalloisopeptidase that hydrolyzes ubiquitin from tagged proteins that are trafficked to the proteasome for degradation. A fragment-based drug discovery (FBDD) approach was utilized to identify fragments with activity against Rpn11. Screening of a library of metal-binding pharmacophores (MBPs) revealed that 8-thioquinoline (8TQ, IC50 value ～2.5 μM) displayed strong inhibition of Rpn11. Further synthetic elaboration of 8TQ yielded a small molecule compound (35, IC50 value ～400 nM) that is a potent and selective inhibitor of Rpn11 that blocks proliferation of tumor cells in culture.

4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS

The present invention relates to compounds of formula (I) or formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R1-R3 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.

Quinoline and phenanthroline preparation starting from glycerol via improved microwave-assisted modified Skraup reaction

An efficient "green" modified Skraup reaction in neat water was developed using inexpensive, abundant and environmentally-friendly glycerol under microwave irradiation conditions. Starting from aniline derivatives, various quinolines were obtained in 10-66% yields. The use of nitroaniline led to the corresponding phenanthrolines in 15-52% yields, respectively. This journal is the Partner Organisations 2014.