635-41-6Relevant articles and documents
In situ protection and deprotection of amines for iron catalyzed oxidative amidation of aldehydes
Bathini, Thulasiram,Rawat, Vikas S.,Bojja, Sreedhar
supporting information, p. 5656 - 5660 (2015/09/15)
An environmentally friendly synthetic route by the application of CO2 to synthesize amides via in situ protection and deprotection of amines for iron catalyzed oxidative amidation of aldehydes was developed. Various secondary and tertiary amides have been synthesized in moderate to good yields under mild and neutral reaction conditions. The use of amine hydrochloride salts and hence base for neutralization step is totally avoided in this protocol.
Silica gel-mediated amide bond formation: An environmentally benign method for liquid-phase synthesis and cytotoxic activities of amides
Yang, Xiao-Dong,Zeng, Xiang-Hui,Zhao, Yuan-Hong,Wang, Xue-Quan,Pan, Zhi-Qiang,Li, Liang,Zhang, Hong-Bin
scheme or table, p. 307 - 310 (2010/11/18)
An efficient, functional group tolerable, and environmentally benign process for the synthesis of amides was developed. No activation reagents or scavengers are required in this process. Purification of desired compounds is easy, rapid, and cost-effective. This protocol provides an alternative for the combinatorial liquid-phase synthesis of amide libraries for drug discovery. By this method, a number of amides were prepared and evaluated in vitro against a panel of human tumor cell lines. Cinnamic amide IV-4 was found to be the most potent compound synthesized against four human tumor cell lines.
Chiral silanes via asymmetric hydrosilylation with catalytic CuH
Lipshutz, Bruce H.,Tanaka, Naoki,Taft, Benjamin R.,Lee, Ching-Tien
, p. 1963 - 1966 (2007/10/03)
CuH-catalyzed asymmetric conjugate reduction of β-silyl-α, β-unsaturated esters has been developed. Using PMHS as a stoichiometric source of hydride and in situ generated CuH ligated by Solvias' JOSIPHOS analogue PPF-P(t-Bu)2 leads to highly enantioselective 1,4-reductions.