63511-92-2Relevant articles and documents
Acidic ionic liquid-catalyzed homologation of the polyene chain in α,β-enals (polyenals)
Kryshtal, Galina V.,Zhdankina, Galina M.,Ignat'Ev, Nikolai V.,Schulte, Michael,Zlotin, Sergei G.
experimental part, p. 173 - 178 (2011/02/27)
An efficient green-chemistry synthesis of conjugated polyenals from α,β-enals, orthoesters, and alkyl vinyl ethers promoted by acidic ionic liquid [emim][HSO4] is described. The ionic liquid can be reused at least three times without any decrease in product yields.
2, 4, 6-SUBSTITUTED PYRIDYL DERIVATIVE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER’S DISEASE
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Page/Page column 59-60, (2010/02/14)
The present invention is directed to 2, 4, 6-substituted pyridyl derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer’s disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
Alkylation of Enol Ethers Obtained by Treatment of α,β-Unsaturated Acetals with Organopotassium Reagents: An Inverse Polarity Approach
Canepa, Carlo,Prandi, Cristina,Sacchi, Luca,Venturello, Paolo
, p. 1875 - 1878 (2007/10/02)
The reaction of α,β-unsaturated acetals 1-4 with sec-butyllithium (2 equiv.) in the presence of potassium tert-butoxide in tetrahydrofuran at -95 deg C gave, as a result of 1,4-elimination, α-metallated enol ethers.The latter react with alkyl halides and carbonyl compounds to afford substitution and addition products.In particular, for the reaction with the acetal 1 and D2O as the electrophile, the α-deuteriated enol ether 5 cyclizes to -2-(prop-1-enyl)-1,3-dioxane.
