63541-20-8

Basic information

• Product Name: 4-((E)-3-PHENYL-ALLYL)-MORPHOLINE
• Synonyms: 4-((E)-3-PHENYL-ALLYL)-MORPHOLINE
• CAS NO: 63541-20-8
• Molecular Formula: C₁₃H₁₇NO
• Molecular Weight: 203.28018
• Mol File: 63541-20-8.mol
• Article Data: 32

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-((E)-3-PHENYL-ALLYL)-MORPHOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((E)-3-PHENYL-ALLYL)-MORPHOLINE(63541-20-8)
• EPA Substance Registry System: 4-((E)-3-PHENYL-ALLYL)-MORPHOLINE(63541-20-8)

Safety Data

• Hazardous Substances Data: 63541-20-8(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 21040-45-9 Cinnamyl acetate 
• 103-54-8 cinnamyl acetate 
• 536-74-3 phenylacetylene 
• 1017-73-8 4-(3-phenyl-prop-2-ynyl)-morpholine 
• 100-58-3 phenylmagnesium bromide 
• 59352-47-5 4-[(2Z)-3-chloroprop-2-en-1-yl]morpholine 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 85620-82-2 (E)-4-cinnamylmorpholine 
• 4392-24-9 Cinnamyl bromide 
• 54664-07-2 1-(2-diphenylphosphinoylethyl)morpholine 
• 114893-66-2 erythro-2-diphenylphosphinoyl-3-morpholino-1-phenylpropyl dimethyl-t-butylsilyl ether 
• 85620-74-2 erythro-2-diphenylphosphinoyl-3-morpholino-1-phenylpropan-1-ol 
• 104-55-2 3-phenyl-propenal 

Downstream Products

• 19199-41-8 C₁₄H₁₇NO₂ 
• 1321123-18-5 4-methyl-4-cinnamylmorpholinium iodide 

Relevant articles and documents

Synthesis of dendrimers with a bidentate phosphine core ligand having carboxy groups at the peripheral layer and their application to aqueous media cross-coupling reactions

We prepared a series of dendrimers with a bidentate phosphine core ligand having carboxy groups at the peripheral layer. By employing the corresponding water-soluble dendritic phosphine-palladium complex as a catalyst, the aqueous media Suzuki-Miyaura rea

Palladium-Based Hydroamination Catalysts Employing Sterically Demanding 3-Iminophosphines: Branched Kinetic Products by Prevention of Allylamine Isomerization

A new allylpalladium triflate catalyst with a dimesitylphosphine moiety was synthesized, isolated, and characterized. The greatly increased steric bulk on the phosphine of this palladium catalyst inhibited product isomerization, which is often observed after hydroamination of terminal allenes with secondary amines. The considerably reduced rate of isomerization facilitated the isolation of many previously unknown branched allylamines, products that were inaccessible when using other, more active 3-iminophosphine palladium catalysts.

A Simple, Broad-Scope Nickel(0) Precatalyst System for the Direct Amination of Allyl Alcohols

The preparation of allylic amines is traditionally accomplished by reactions of amines with reactive electrophiles, such as allylic halides, sulfonates, or oxyphosphonium species; such methods involve hazardous reagents, generate stoichiometric waste streams, and often suffer from side reactions (such as overalkylation). We report here the first broad-scope nickel-catalysed direct amination of allyl alcohols: An inexpensive NiII/Zn couple enables the allylation of primary, secondary, and electron-deficient amines without the need for glove-box techniques. Under mild conditions, primary and secondary aliphatic amines react smoothly with a range of allyl alcohols, giving secondary and tertiary amines efficiently. This “totally catalytic” method can also be applied to electron-deficient nitrogen nucleophiles; the practicality of the process was demonstrated in an efficient, gram-scale preparation of the calcium antagonist drug substance flunarizine (Sibelium).