635712-46-8

Basic information

• Product Name: 2-Propenoic acid, 3-(7-chloro-1H-indazol-5-yl)-2-[[(phenylmethoxy)carbonyl]amino]-, methyl ester
• CAS NO: 635712-46-8
• Molecular Formula: C19H16ClN3O4
• Mol File: 635712-46-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-(7-chloro-1H-indazol-5-yl)-2-[[(phenylmethoxy)carbonyl]amino]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-(7-chloro-1H-indazol-5-yl)-2-[[(phenylmethoxy)carbonyl]amino]-, methyl ester(635712-46-8)
• EPA Substance Registry System: 2-Propenoic acid, 3-(7-chloro-1H-indazol-5-yl)-2-[[(phenylmethoxy)carbonyl]amino]-, methyl ester(635712-46-8)

Safety Data

• Hazardous Substances Data: 635712-46-8(Hazardous Substances Data)

Upstream product

• 635712-44-6 5-bromo-7-chloro-1H-indazole 
• 30273-42-8 2-methyl-4-bromo-6-chloroaniline 
• 635712-45-7 7-Chloroindazole-5-carboxaldehyde 
• 100945-15-1 N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester 

Relevant articles and documents

The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 2

Various substituted indazole and benzoxazolone amino acids were investigated as d-tyrosine surrogates in highly potent CGRP receptor antagonists. Compound 3, derived from the 7-methylindazole core, afforded a 30-fold increase in CGRP binding potency compared with its unsubstituted indazole analog 1. When dosed at 0.03 mg/kg SC, compound 2 (a racemic mixture of 3 and its (S)-enantiomer) demonstrated robust inhibition of CGRP-induced increases in mamoset facial blood flow up to 105 min. The compound possesses a favorable predictive in vitro toxicology profile, and good aqueous solubility. When dosed as a nasal spray in rabbits, 3 was rapidly absorbed and showed good intranasal bioavailability (42%).