63597-44-4 Usage
Description
4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE, also known as 4α-PMA, is a non-tumor promoting phorbol ester derivative. It is structurally similar to PMA, a tumor promoter and activator of protein kinase C (PKC). However, 4α-PMA has been used as a negative control for PMA due to its weaker tumor promoting properties. It has also been found to be a potent activator of TRPV4 channels, making it a valuable tool for structure-activity investigations.
Uses
Used in Research Applications:
4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE is used as a negative control for PMA in research studies, particularly in the field of protein kinase C (PKC) activation and tumor promotion. It helps researchers differentiate the effects of PMA from other compounds in their experiments.
Used in Pharmaceutical Industry:
4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE is used as a reasonably potent activator of TRPV4 channels for structure-activity investigations. It is compared to the very similar compound, 4α-PDD, which demonstrates 50 times more affinity for TRPV4. This comparison aids in understanding the structure-activity relationship of these compounds and their potential therapeutic applications.
Used in Skin Care Research:
In skin care research, 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE has been shown to significantly increase PGHS-2 mRNA in murine keratinocytes. This finding suggests its potential use in studying the regulation of prostaglandin synthesis and its implications in skin health and disease.
Biochem/physiol Actions
Negative control for phorbol ester activation of protein kinase C.
Check Digit Verification of cas no
The CAS Registry Mumber 63597-44-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,5,9 and 7 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 63597-44:
(7*6)+(6*3)+(5*5)+(4*9)+(3*7)+(2*4)+(1*4)=154
154 % 10 = 4
So 63597-44-4 is a valid CAS Registry Number.
InChI:InChI=1/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34+,35-,36-/m1/s1
