63659-16-5 Usage
Description
4-[2-(Cyclopropylmethyl)ethoxy]phenol, also known as Betaxolol EP Impurity D, is an organic compound that serves as an intermediate in the synthesis of Betaxolol. It is characterized by its unique molecular structure, which includes a cyclopropylmethoxyethyl group attached to a phenol moiety.
Uses
Used in Pharmaceutical Industry:
4-[2-(Cyclopropylmethyl)ethoxy]phenol is used as a key intermediate in the synthesis of Betaxolol, a medication used to treat high blood pressure and glaucoma. Its role in the synthesis process is crucial for the production of this therapeutically valuable drug.
As an intermediate in the synthesis of Betaxolol, 4-[2-(Cyclopropylmethyl)ethoxy]phenol plays a vital role in the pharmaceutical industry, contributing to the development and manufacturing of medications that help manage blood pressure and eye pressure conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 63659-16-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,6,5 and 9 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 63659-16:
(7*6)+(6*3)+(5*6)+(4*5)+(3*9)+(2*1)+(1*6)=145
145 % 10 = 5
So 63659-16-5 is a valid CAS Registry Number.
InChI:InChI=1/C12H16O2/c13-12-5-3-10(4-6-12)7-8-14-9-11-1-2-11/h3-6,11,13H,1-2,7-9H2
63659-16-5Relevant articles and documents
PROCESS FOR PREPARATION OF PHENOXYPROPANOL AMINES
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Page/Page column 8, (2010/04/06)
The present invention describes an improved method for the preparation of l-[4-{2- (cyclopropylmethoxy)ethyl}phenoxy]-3-[(1-methylethyl)amino]-2-propanol of Formula-(I) and its pharmaceutically acceptable salt, which comprises reacting 4 - [ 2 — (Cyclopropylmethoxy) ethyl] phenol with epichlorohydrin in presence of mild base and polar protic solvent to isolate 1 - {4 - [2 - (cyclopropylmethoxy)ethyl] - phenoxy} - 2, 3 - epoxy propane, which is further reacted with isopropyl amine to get betaxolol formula (I).
PROCESS FOR PREPARATION OF S-(-)-BETAXOLOL AND SALTS THEREOF
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Page/Page column 3-5, (2010/02/15)
The present invention relates to an improved process for preparation of S-(?)-betaxolol salts. More particularly the present invention relates to the preparation of hydrochloride salt of S-(?)-betaxolol of formula (1).
Synthesis of a series of compounds related to betaxolol, a new β1-adrenoceptor antagonist with a pharmacological and pharmacokinetic profile optimized for the treatment of chronic cardiovascular diseases
Manoury,Binet,Rousseau,Lefevre-Borg,Cavero
, p. 1003 - 1011 (2007/10/02)
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