63660-21-9 Usage
Description
5'-DMT-5-BROMO-DU PHOSPHORAMIDITE (CHIRAL) is a chemical compound that serves as a key building block in the synthesis of nucleic acid analogs and modified oligonucleotides. It is characterized by the presence of a 5-bromo-2'-deoxyuridine moiety, which is protected by a 5'-dimethoxytrityl (DMT) group. 5'-DMT-5-BROMO-DU PHOSPHORAMIDITE (CHIRAL) is chiral, meaning it has a non-superimposable mirror image, and is essential for the development of various therapeutic agents.
Uses
Used in Pharmaceutical Industry:
5'-DMT-5-BROMO-DU PHOSPHORAMIDITE (CHIRAL) is used as a precursor in the synthesis of modified nucleic acids for the development of potential antivirals, antibacterials, antifungals, and antineoplastics. The unique properties of this compound, such as the bromine atom and the chiral center, allow for the creation of novel therapeutic agents with improved specificity and efficacy against various diseases.
In the development of antivirals, this compound can be incorporated into oligonucleotides that target and inhibit the replication of viral genomes, thereby preventing the spread of viral infections.
In the context of antibacterial applications, 5'-DMT-5-BROMO-DU PHOSPHORAMIDITE (CHIRAL) can be used to create modified oligonucleotides that target and disrupt the function of essential bacterial genes, leading to the inhibition of bacterial growth and proliferation.
For antifungal purposes, this compound can be utilized to design oligonucleotides that specifically target fungal RNA or DNA, thereby inhibiting fungal growth and reducing the severity of fungal infections.
In the field of antineoplastics, 5'-DMT-5-BROMO-DU PHOSPHORAMIDITE (CHIRAL) can be employed to synthesize modified nucleic acids that target cancer-related genes or pathways, leading to the suppression of tumor growth and the enhancement of cancer treatment outcomes.
Overall, 5'-DMT-5-BROMO-DU PHOSPHORAMIDITE (CHIRAL) is a versatile and essential compound in the pharmaceutical industry, playing a crucial role in the development of innovative therapeutic agents for various medical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 63660-21-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,6,6 and 0 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 63660-21:
(7*6)+(6*3)+(5*6)+(4*6)+(3*0)+(2*2)+(1*1)=119
119 % 10 = 9
So 63660-21-9 is a valid CAS Registry Number.
63660-21-9Relevant articles and documents
Improved synthesis of 5-hydroxymethyl-2′-deoxycytidine phosphoramidite using a 2′-deoxyuridine to 2′-deoxycytidine conversion without temporary protecting groups
Hansen, Anders S.,Thalhammer, Armin,El-Sagheer, Afaf H.,Brown, Tom,Schofield, Christopher J.
, p. 1181 - 1184 (2011/04/16)
5-Hydroxymethylcytosine has recently been characterized as the 'sixth base' in human DNA. To enable research on this DNA modification, we report an improved method for the synthesis of 5-hydroxymethyl-2′-deoxycytidine (5-HOMedC) phosphoramidite for site-specific incorporation into oligonucleotides. To minimize manipulations we employed a temporary protecting group-free 2′-deoxyuridine to 2′-deoxycytidine conversion procedure that utilizes phase transfer catalysis. The desired 5-HOMedC phosphoramidite is obtained in six steps and 24% overall yield from 2′-deoxyuridine.
Evaluation of oligonucleotides with novel modifications
Larsen,Danel,Abdel-Aleem,Nielsen,Wengel,Pedersen
, p. 1097 - 1100 (2007/10/02)
Oligodeoxynucleotides modified with carboxamide linked dimeric nucleotides and an acyclic nucleoside were prepared and investigated for their hybridization properties toward DNA.
