63697-96-1Relevant articles and documents
A fluorescent probe for the 3′-overhang of telomeric DNA based on competition between two interstrand G-quadruplexes
Kim, Ki Tae,Kim, Byeang Hyean
, p. 1717 - 1719 (2013)
A 6-mer oligonucleotide containing a fluorescent BodU moiety has been used as a novel fluorescent probe for the 3′-overhang of telomeric DNA based on competition between non-fluorescent tetramolecular and fluorescent (3+1) intermolecular G-quad
Synthesis, characterization, electrochemistry and photophysical studies of rhenium(I) tricarbonyl diimine complexes with carboxaldehyde alkynyl ligands Dedicated to Professor Claude Lapinte for his contribution to organometallic chemistry.
Lam, Siu-Tung,Zhu, Nianyong,Au, Vonika Ka-Man,Yam, Vivian Wing-Wah
, p. 10 - 16 (2015)
A class of rhenium(I) tricarbonyl diimine complexes with carboxaldehyde alkynyl ligands, [Re(CO)3(N^N)(CC-C6H4-CHO)] (N^N = α,α′-diimine ligand), has been successfully synthesized and characterized, and the X-ray crystal structure of one of the complexes has been determined. Electrochemical and photophysical studies have been performed to study the effect of the variation of the diimine ligand on the redox and optical properties of the rhenium(I) complexes.
Ionic liquids enhanced alkynyl schiff bases derivatives of fipronil synthesis and their cytotoxicity studies
Liu, Xiu,Huang, Linya,Chen, Hongjun,Li, Na,Yan, Chao,Jin, Chenzhong,Xu, Hanhong
, (2019)
To obtain highly selective toxic derivatives of fipronil, a series of Schiff bases with an alkynyl group (3a–3k) were designed and synthesized from 4-ethynylbenzaldehyde (2) and 4-substituted 5-amino-N-arylpyrazole (1a–1k) via a nucleophilic addition elim
Helical poly(phenylacetylene)s containing schiff-base and amino groups: Synthesis, secondary structures, and responsiveness to benzoic acid
Zhang, Yu,Gao, Keke,Zhao, Zhongfu,Yue, Dongmei,Hu, Yanming,Masuda, Toshio
, p. 5248 - 5256 (2013)
Novel acetylenic monomers containing Schiff-base and amino groups, (S)-N-(4-ethynylbenzylidene)-1-phenylethanamine (1a), (R)-N-(4- ethynylbenzylidene)-1-phenylethanamine (1b), N-(4-ethynylbenzylidene)-1- phenylethanamine (1c), (R)-N-(4-ethynylbenzyl)-1-ph
A high-performance photoelectrochemical sensor for the specific detection of H2O2and glucose based on an organic conjugated microporous polymer
Chen, Yanli,Gao, Wen,Kong, Xia,Li, Xiyou,Liu, Qi,Liu, Xue,Shen, Jingshun,Sun, Qiqi,Xing, Chuanwang,Zhang, Yuexing
supporting information, p. 26216 - 26225 (2021/12/13)
Cathodic photoelectrochemical (PEC) biosensors are one of ideal systems for sensing applications owing to their advantages in the low-cost, simplicity of the detection and miniaturization of the sensors with high sensitivity and specificity. Herein, a high-performance PEC sensor based on a 2D porphyrin-phthalocyanine conjugated microporous polymer (PorPc-CMP) is reported for the specific detection of H2O2 and glucose in the wide linear ranges of 0.05-100 and 0.05-5000 μM with an ultra-low limit of detection (LOD) of 13 and 27 nM, respectively. All of them achieved the best levels, when compared to H2O2 and glucose tetrapyrrole-based photoelectrochemical sensors reported so far. After a comparative analysis on the morphology, optical-electrical properties and partial charge density plots by DFT calculations for the PorPc-CMP and its analogues (PorPor-CMP and PcPc-CMP), it is revealed that the high PEC-sensing performance of PorPc-CMP is largely related to the synergistic effect of unique multi-channel D-A structure and elaborate hollow tube-like morphology, which leads to the effective charge separation, enhanced charge transportability and high utilization of light irradiation. Furthermore, good accuracy of the PorPc-CMP PEC sensor was demonstrated in real sample analysis of H2O2 disinfectant and human serum samples. This journal is
RET INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
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Paragraph 00324-00325, (2020/07/06)
Provided herein are a RET inhibitor, a pharmaceutical composition thereof and uses thereof. In particular, provided is a compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. Provided is a pharmaceutical composition comprising the compound, and uses of the compound and pharmaceutical composition thereof for the preparation of a medicament, in particular for treatment and prevention of RET-related diseases and conditions, including cancer, irritable bowel syndrome, and/or pain associated with irritable bowel syndrome.