637-03-6 Usage
Description
Phenylarsine oxide (PhAsO4), also known as an arsine oxide derived from phenylarsine, is a bifunctional SH group chemical that is hydrophobic in nature. It is characterized by its white to almost white crystalline appearance.
Uses
Used in Veterinary Medicine:
Phenylarsine oxide is utilized as a poultry coccidiostat in the veterinary medicine industry. It serves as a preventive measure against coccidiosis, a parasitic disease affecting poultry, by inhibiting the growth and reproduction of the causative protozoan parasites.
Used in Biochemistry and Molecular Biology:
Phenylarsine oxide is employed as a membrane-permeable protein tyrosine phosphatase inhibitor. This application is crucial in various research and diagnostic processes, as it helps regulate the activity of protein tyrosine phosphatases, which are essential enzymes involved in cellular signaling and regulation. By inhibiting these enzymes, researchers can study their roles in cellular processes and develop potential therapeutic strategies for various diseases.
Biochem/physiol Actions
Phenylarsine oxide?(PAO) can reduce the motility and sustainability of Setaria cervi. It has the ability to stimulate cyclosporin A-sensitive transition in the presence of EGTA (ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid). It acts as a stimulator of mitochondrial ion fluxes.
Safety Profile
Poison by intravenous and intraperitoneal routes. When heated to decomposition it emits toxic fumes of As. See also ARSENIC COMPOUNDS
Check Digit Verification of cas no
The CAS Registry Mumber 637-03-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,3 and 7 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 637-03:
(5*6)+(4*3)+(3*7)+(2*0)+(1*3)=66
66 % 10 = 6
So 637-03-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H5AsO/c8-7-6-4-2-1-3-5-6/h1-5H
637-03-6Relevant articles and documents
Kinetics of the reactions of [Chloro(phenyl)arsanyl]acetic acid with bromo- and iodoacetic acids
Rakhmatullin,Selyutina,Gavrilov,Musin
scheme or table, p. 378 - 382 (2009/06/28)
Quternization of [chloro(phenyl)arsanyl]acetic acid with bromo- and iodoacetic acids in aqueous alkali follows SN2 mechanism and is accompanied by alkaline hydrolysis of haloacetic acids. The rate constants and thermodynamic parameters of the process were determined
