63701-55-3 Usage
Description
R(+)-BACLOFEN HYDROCHLORIDE, a derivative of gamma-aminobutyric acid (GABA), is a potent and selective agonist of the GABA-B receptor. It is a chiral molecule, with the R-enantiomer being the active form responsible for its therapeutic effects. R(+)-BACLOFEN HYDROCHLORIDE is characterized by its ability to modulate neuronal excitability and has been found to be effective in various medical applications.
Uses
Used in Pharmaceutical Industry:
R(+)-BACLOFEN HYDROCHLORIDE is used as a therapeutic agent for the treatment of spasticity, a condition characterized by increased muscle stiffness and involuntary muscle contractions. It is particularly effective in managing spasticity associated with conditions such as multiple sclerosis, spinal cord injuries, and other neurological disorders. The application of R(+)-BACLOFEN HYDROCHLORIDE in this context is due to its ability to reduce neuronal excitability and muscle tone, providing relief from spasticity symptoms.
Additionally, R(+)-BACLOFEN HYDROCHLORIDE has been explored for its potential use in treating other conditions, such as alcohol dependence, overactive bladder, and certain movement disorders. Its application in these areas is based on its ability to modulate GABA-B receptors, which play a role in regulating various physiological processes and behaviors. However, further research is needed to fully understand its efficacy and safety in these contexts.
Biochem/physiol Actions
R(+)-Baclofen is a GABAB receptor agonist; more active enantiomer; skeletal muscle relaxant.
Check Digit Verification of cas no
The CAS Registry Mumber 63701-55-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,7,0 and 1 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 63701-55:
(7*6)+(6*3)+(5*7)+(4*0)+(3*1)+(2*5)+(1*5)=113
113 % 10 = 3
So 63701-55-3 is a valid CAS Registry Number.
InChI:InChI=1/C10H12ClNO2.ClH/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14;/h1-4,8H,5-6,12H2,(H,13,14);1H/t8-;/m0./s1
63701-55-3Relevant articles and documents
Polysulfonate supported chiral diamine-nickel catalysts: Synthesis and applications
Zhou, Jing-xuan,Zhu, Dong-yu,Chen, Jie,Zhang, Xue-jing,Yan, Ming,Chan, Albert S.C.
supporting information, (2021/01/25)
A series of chiral polysulfonate cyclohexyldiamine-Ni(II) catalysts were prepared via sulfur (VI) fluoride exchange click-reactions. The catalysts exhibited good catalytic activity and enantioselectivity in the Michael addition of malonates to nitroalkene
Highly Enantioselective Synthesis of Chiral γ-Lactams by Rh-Catalyzed Asymmetric Hydrogenation
Lang, Qiwei,Gu, Guoxian,Cheng, Yaoti,Yin, Qin,Zhang, Xumu
, p. 4824 - 4828 (2018/06/08)
A Rh/bisphosphine-thiourea (ZhaoPhos) catalytic system has been identified for the straightforward asymmetric synthesis of chiral γ-lactams. A variety of NH free α,β-unsaturated lactams bearing a β-aryl or β-alkyl substituent were smoothly hydrogenated to
Enantioselective conjugate hydrocyanation of α,β-unsaturated N-acylpyrroles catalyzed by chiral lithium(I) phosphoryl phenoxide
Hatano, Manabu,Yamakawa, Katsuya,Ishihara, Kazuaki
, p. 6686 - 6690 (2017/11/09)
Enantioselective conjugate hydrocyanation of α,β-unsaturated N-acylpyrroles with the combined use of Me3SiCN, LiCN, and HCN has been developed in the presence of a chiral lithium(I) phosphoryl phenoxide catalyst. This reaction is useful for a v