637330-41-7Relevant articles and documents
A new paclitaxel prodrug for use in ADEPT strategy
Bouvier, Emmanuel,Thirot, Sylvie,Schmidt, Frederic,Monneret, Claude
, p. 3343 - 3352 (2007/10/03)
A new paclitaxel prodrug intended for use in Antibody-Directed Prodrug Therapy (ADEPT) or Prodrug Monotherapy (PMT) has been prepared. This prodrug was originally designed to be activated into the drug by human β-glucuronidase. In order to enhance the liberation rate of paclitaxel, an elongated spacer system including a nitro-aromatic derivative and a N,N′-methylethylenediamine was incorporated between the sugar moiety and the drug. Indeed, this new prodrug proved to be activated significantly faster than a former paclitaxel prodrug containing a conventional spacer.