637354-25-7

Basic information

• Product Name: 2-(Methylsulfonyl)-4-(pyridin-3-yl) pyriMidine
• Synonyms: 2-(Methylsulfonyl)-4-(pyridin-3-yl) pyriMidine
• CAS NO: 637354-25-7
• Molecular Formula: C10H9N3O2S
• Molecular Weight: 235.26236
• EINECS: 604-604-1
• Mol File: 637354-25-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(Methylsulfonyl)-4-(pyridin-3-yl) pyriMidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Methylsulfonyl)-4-(pyridin-3-yl) pyriMidine(637354-25-7)
• EPA Substance Registry System: 2-(Methylsulfonyl)-4-(pyridin-3-yl) pyriMidine(637354-25-7)

Safety Data

• Hazardous Substances Data: 637354-25-7(Hazardous Substances Data)

Usage

General Description

2-(Methylsulfonyl)-4-(pyridin-3-yl) pyriMidine, also known as Metyrapone, is a medication and potent inhibitor of cortisol synthesis. It works by blocking the enzyme 11β-hydroxylase, which is involved in the synthesis of cortisol in the adrenal glands. As a result, Metyrapone is used in the diagnosis of adrenal insufficiency and the treatment of certain adrenal gland disorders. It has also been investigated for its potential use in the treatment of Cushing's syndrome, a condition characterized by excess cortisol production. Additionally, Metyrapone has been studied in the context of cognitive function and memory enhancement. However, its use is associated with potential side effects, including nausea, dizziness, and drowsiness, and it should be used with caution under the supervision of a healthcare professional.

Upstream product

• 55314-16-4 (E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one 
• 55314-16-4 3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one 
• 637354-24-6 2-(methylsulfanyl)-4-(3-pyridyl)pyrimidine 

Relevant articles and documents

Synthetic method of N-(2-methyl-5-aminophenyl)-4-(3-pyridyl)-2-pyrimidinamine

The invention discloses a synthetic method of N-(2-methyl-5-aminophenyl)-4-(3-pyridyl)-2-pyrimidinamine. The synthetic method comprises the following steps: (1) synthesizing 2-(methylthio)-4-(3-pyridyl) pyrimidine; (2) synthesizing 2-(methylsulfonyl)-4-(3-pyridine) pyrimidine; (3) synthesizing N-(2-methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidinamine and (4) synthesizing the N-(2-methyl-5-aminophenyl)-4-(3-pyridyl)-2-pyrimidinamine. Synthesis raw materials used in the method are low in price and easy to obtain, reaction conditions are mild, the product yield and purity are high, and the methodis suitable for industrial production. Therefore, the synthetic method disclosed by the invention has good advantages in the aspects of production cost control, environmental friendliness and productquality improvement.

A novel synthesis of imatinib and its intermediates

A convenient method has been developed for the synthesis of imatinib and two of its intermediates. N-(2-Methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidin amine, obtained from 2-(methylsulfonyl)-4-(3-pyridyl)pyrimidine via nucleophilic substitution, was reduced by N2H4H2O/FeCl 3·6H2O/C in 92% yield. The resulting amine was condensed with 4-[(4-methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride, which was prepared from 4-(chloromethyl)benzonitrile via substitution and hydrolysis reactions, to provide the final product imatinib in good yield and high purity. Springer-Verlag 2010.