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6375-47-9

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  • 3-Amino-4-Methoxy Acetanilide 6375-47-9 Manufacturer High quality Best price In stock factory N-(3-amino-4-methoxyphenyl)acetamide 2-Amino-4-acetamino anisole 6375-47-9

    Cas No: 6375-47-9

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6375-47-9 Usage

General Description

3'-Amino-4'-methoxyacetanilide, also known as acetaminophen, is a widely used over-the-counter pain reliever and fever reducer. It is a synthetic compound with analgesic and antipyretic properties, often used to alleviate mild to moderate physical discomfort associated with conditions such as headaches, muscle aches, arthritis, and colds. Acetaminophen works by inhibiting the production of prostaglandins, which are chemicals in the body that promote pain and fever. It is considered a safe and effective medication when taken in appropriate doses, but excessive consumption can lead to liver damage and other serious complications. Therefore, it is important to use this chemical responsibly and as directed by a healthcare professional.

Check Digit Verification of cas no

The CAS Registry Mumber 6375-47-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,3,7 and 5 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 6375-47:
(6*6)+(5*3)+(4*7)+(3*5)+(2*4)+(1*7)=109
109 % 10 = 9
So 6375-47-9 is a valid CAS Registry Number.
InChI:InChI=1/C22H19NO5/c1-27-19-11-13(7-9-17(19)24)22(14-8-10-18(25)20(12-14)28-2)15-5-3-4-6-16(15)23-21(22)26/h3-12,24-25H,1-2H3,(H,23,26)

6375-47-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 3'-Amino-4'-methoxyacetanilide

1.2 Other means of identification

Product number -
Other names N-(3-amino-4-methoxyphenyl)acetamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6375-47-9 SDS

6375-47-9Synthetic route

2-nitro-4-acetylamino-anisole
50651-39-3

2-nitro-4-acetylamino-anisole

formic acid hydrazide
624-84-0

formic acid hydrazide

3-amino-4-methoxyacetanilide
6375-47-9

3-amino-4-methoxyacetanilide

Conditions
ConditionsYield
With palladium on activated charcoal In methanol at 20℃;99.5%
2,4-Diaminoanisole
615-05-4

2,4-Diaminoanisole

acetic anhydride
108-24-7

acetic anhydride

3-amino-4-methoxyacetanilide
6375-47-9

3-amino-4-methoxyacetanilide

Conditions
ConditionsYield
With sodium carbonate In methanol at 5℃; for 0.00416667h; Temperature; Concentration; Reagent/catalyst; Time;99%
With sodium carbonate In methanol at 5℃; Reagent/catalyst; Temperature;98.6%
In methanol at 0 - 5℃; for 1.16667h; Solvent; Large scale;98.5%
3-amino-4-methoxyacetanilide

3-amino-4-methoxyacetanilide

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen In methanol at 50℃; under 4500.45 Torr; for 0.416667h;98.1%
With hydrogen In methanol at 60℃; under 11251.1 Torr;96.52%
With hydrogen at 80℃; under 7500.75 Torr; Large scale;96.52%
3-amino-4-methoxyacetanilide

3-amino-4-methoxyacetanilide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: PEG4000 / 60 °C / Large scale
2: hydrogen / methanol / 60 °C / 4500.45 Torr / pH 9
3: sodium carbonate / methanol / 5 °C
View Scheme
Multi-step reaction with 4 steps
1: sodium hydroxide / 3 h / 60 °C
2: PdCu/graphene double-metal catalyst / 0.58 h / 60 °C / 7500.75 Torr
3: ammonium bicarbonate / methanol / -5 - 5 °C
4: palladium on activated charcoal; hydrogen / methanol / 0.42 h / 50 °C / 4500.45 Torr
View Scheme
Multi-step reaction with 3 steps
1: sodium hydroxide / water / 35 - 65 °C
2: sodium disulfide / water / 80 °C
3: acetic acid; triethylamine / 2.5 h / 0 - 5 °C
View Scheme
Multi-step reaction with 3 steps
1: PEG2000 / methanol / 60 °C
2: palladium on activated charcoal; formic acid hydrazide / methanol
3: magnesium oxide / methanol / -5 - 5 °C
View Scheme
Multi-step reaction with 3 steps
1: PEG4000 (polyethyleneglycol 4000) / 60 °C
2: hydrogen / methanol / 40 °C / 30003 Torr / Autoclave
3: sodium carbonate / methanol / -5 - 5 °C
View Scheme
3-amino-4-methoxyacetanilide

3-amino-4-methoxyacetanilide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: palladium 10% on activated carbon / methanol / 30 - 40 °C / 375.04 - 1500.15 Torr / Inert atmosphere
2: sulfuric acid; nitric acid / 3 h
3: palladium 10% on activated carbon / methanol / 30 - 40 °C / 375.04 - 1500.15 Torr / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: hydrogen / methanol / 80 °C / 9000.9 Torr / Large scale
2: 8 h / 190 °C
3: nitric acid; sulfuric acid / water / 12 h / 0 - 5 °C
4: hydrogen / methanol / 60 °C / 11251.1 Torr
View Scheme
Multi-step reaction with 4 steps
1: hydrogen; / methanol / 100 °C / 15001.5 Torr / Large scale
2: 200 °C / Large scale
3: sulfuric acid; nitric acid / 5 °C / Large scale
4: hydrogen; / 80 °C / 7500.75 Torr / Large scale
View Scheme

6375-47-9Relevant articles and documents

Hydrogenation of 3-nitro-4-methoxy-acetylaniline with H2 to 3-amino-4-methoxy-acetylaniline catalyzed by bimetallic copper/nickel nanoparticles

Yang, Chenchen,Xue, Wuping,Yin, Hengbo,Lu, Zhipeng,Wang, Aili,Shen, Lingqin,Jiang, Yunyan

, p. 3358 - 3366 (2017)

Monometallic Cu, monometallic Ni, and bimetallic CuxNiy nanoparticles were prepared by a wet chemical reduction method. A Cu-Ni alloy phase was formed in the bimetallic CuxNiy nanoparticles. The bimetallic CuxNiy nanoparticles exhibited higher catalytic activity for the hydrogenation of 3-nitro-4-methoxy-acetylaniline (NMA) to 3-amino-4-methoxy-acetylaniline (AMA) with H2 than the sole Ni nanoparticles, which was ascribed to the effect of the Cu-Ni alloy phase. When the reaction was catalyzed over the bimetallic Cu0.7Ni0.3 catalyst at 140 °C for 2 h, the AMA selectivity was 99.4% when the NMA conversion was 95.7%. The reaction activation energy for NMA hydrogenation was 19.74 kJ mol-1.

Synthesis process of 2-amidogen-4-acetamido anisole

-

Paragraph 0044; 0044-0046; 0048-0049; 0051-0052; 0054, (2020/03/28)

The invention discloses a synthesis process of 2-amidogen-4-acetamido anisole. The synthesis process of the 2-amidogen-4-acetamido anisole comprises the steps of adopting p-methoxyaniline as a raw material, carrying out partial acylation reaction on the p-methoxyaniline and acetic anhydride, and preparing to obtain p-acetamido anisole; then carrying out nitration reaction, carrying out one-pot method'reaction to obtain 2-nitro-4-acetamido anisole, and under the action of a Pd/C catalyst, reducing the 2-nitro-4-acetamido anisole by adopting hydrazine monoformate as a hydrogen source to preparethe 2-amidogen-4-acetamido anisole. The synthesis process provided by the invention is low in energy consumption, low in cost, less in solid wastes and waste liquids, green and environmentally friendly, simple to operate, mild in reaction conditions, and high in industrial safety coefficient, the total yield of the target compound is 85 percent or above (on the basis of an initial reaction raw material), the HPLC (High Performance Liquid Chromatography) purity is 99.0 percent or above, the target compound is high in yield and good in quality, and the synthesis process is more suitable for industrial production.

2 - Amino - 4 - acetamido anisole novel synthesis process (by machine translation)

-

, (2018/03/01)

The present invention provides a novel 2 - amino - 4 - acetamido anisole synthesis process, the usage of palladium bi-metal catalysts and the palladium/carbon catalyst to replace Rany - Ni catalyst, to the anisole on the nitro-selective catalytic hydrogenation, which not only reduces use Rany - Ni catalyst of post-industrial risks, while at the same time, the resulting 2 - amino - 4 - acetyl anisole purity higher, greater yield. (by machine translation)

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