63763-66-6

Basic information

• Product Name: 4-Benzyl-piperazine-1-carbonylchloride
• Synonyms: 4-Benzylpiperazine-1-carbonyl chloride
• CAS NO: 63763-66-6
• Molecular Formula: C₁₂H₁₅ClN₂O
• Molecular Weight: 238.71
• Mol File: 63763-66-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 92 °C
• Boiling Point: 359.8 °C at 760 mmHg
• Flash Point: 171.4 °C
• Appearance: /
• Density: 1.236 g/cm³
• Vapor Pressure: 2.32E-05mmHg at 25°C
• Refractive Index: 1.579
• PKA: 6.21±0.10(Predicted)
• CAS DataBase Reference: 4-Benzyl-piperazine-1-carbonylchloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Benzyl-piperazine-1-carbonylchloride(63763-66-6)
• EPA Substance Registry System: 4-Benzyl-piperazine-1-carbonylchloride(63763-66-6)

Safety Data

• Hazardous Substances Data: 63763-66-6(Hazardous Substances Data)

Usage

General Description

4-Benzyl-piperazine-1-carbonylchloride is a chemical compound with the molecular formula C14H16ClN2O. It is a carbonylchloride derivative of piperazine that is used in the synthesis of pharmaceutical compounds and organic molecules. 4-Benzyl-piperazine-1-carbonylchloride is commonly used as a building block in the production of various drugs and agrochemicals. It is an important intermediate in the pharmaceutical industry for the production of antipsychotic and antidepressant drugs. The presence of a carbonylchloride group in the molecule makes it a versatile reagent for the synthesis of complex organic compounds. It is also used as a research chemical in organic chemistry laboratories for the development of new chemical reactions and synthetic pathways. Overall, 4-Benzyl-piperazine-1-carbonylchloride is an important and versatile compound with various applications in the pharmaceutical and chemical industries.

InChI:InChI=1/C12H15ClN2O/c13-12(16)15-8-6-14(7-9-15)10-11-4-2-1-3-5-11/h1-5H,6-10H2

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 148120-38-1 1-(phenylmethyl)-4-[(4'-methoxyphenyl)methyl]piperazine 
• 2759-28-6 1-phenylmethylpiperazine 

Downstream Products

• 1416356-21-2 (E)-3,5,4'-tri[(N-benzylpiperazine-N'-carbonyl)oxy]stilbene 
• 1416355-88-8 (E)-(4-(3,5-dimethoxystyryl)phenyl) N-benzylpiperazine-N'-carboxylate 
• 75529-71-4 N,N-diethyl-N'-(4-(phenylmethyl)piperazinyl)urea 

Relevant articles and documents

Design, synthesis and biological evaluation of 4'-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease

A series of 4'-aminochalcone-revastigmine hybrids were designed, synthesized and evaluated as multifunctional agents for the treatment of Alzheimer's disease. The results showed that most of these compounds exhibited good multifunctional activities. In particular, compound 6c displayed the best inhibitory potency on acetylcholinesterase (IC50= 4.91 μM), and significant antioxidative activity with a value 2.83-fold of Trolox. The kinetic analysis of AChE inhibition revealed that 6c showed mixed-type inhibition, binding simultaneously to the catalytic active site and peripheral anionic site of AChE. In addition, 6c inhibited self-induced Aβ1-42aggregation and Cu2+-induced Aβ1-42aggregation by 89.5% and 79.7% at 25 μM respectively, as well as acted as a selective monoamine oxidase B inhibitor (IC50= 0.29 μM) and a selective biometal chelator. Furthermore, 6c could cross the blood-brain barrier in vitro. Based on these results, Compound 6c could be considered as a very promising lead compound for Alzheimer's disease.

Synthesis of pterostilbene and resveratrol carbamate derivatives as potential dual cholinesterase inhibitors and neuroprotective agents

Pterostilbene and resveratrol carbamate derivatives were designed and synthesized by use of a multi-target directed drug-design strategy. Their acetylcholinesterase and butylcholinesterase inhibitory activity and neuroprotective effects against hydrogen peroxide-induced PC12 cell injury were evaluated in vitro. The results indicated that some of the compounds had dual inhibitory potency against acetylcholinesterase and butylcholinesterase, and potential neuroprotective effects, and could be considered as potential multi-target-directed agents.