6378-90-1

Basic information

• Product Name: N-(4-(4-acetamido-3-nitrophenyl)-2-nitrophenyl)acetamide
• Synonyms: N-(4-(4-acetamido-3-nitrophenyl)-2-nitrophenyl)acetamide;2',2'''-Dinitro-4',4'''-biacetanilide;N,N'-(3,3'-Dinitro[1,1'-biphenyl]-4,4'-diyl)bis-acetaMide;1,1-(4,4-Diamino-3,3-dinitro-[1,1-biphenyl]-2,6-diyl)diethanone
• CAS NO: 6378-90-1
• Molecular Formula: C₁₆H₁₄N₄O₆
• Molecular Weight: 358.30556
• Product Categories: Aromatics
• Mol File: 6378-90-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-(4-acetamido-3-nitrophenyl)-2-nitrophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-(4-acetamido-3-nitrophenyl)-2-nitrophenyl)acetamide(6378-90-1)
• EPA Substance Registry System: N-(4-(4-acetamido-3-nitrophenyl)-2-nitrophenyl)acetamide(6378-90-1)

Safety Data

• Hazardous Substances Data: 6378-90-1(Hazardous Substances Data)

Usage

Description

N-(4-(4-acetamido-3-nitrophenyl)-2-nitrophenyl)acetamide is a complex organic compound with a unique chemical structure. It is characterized by its yellow solid appearance and is known for its utility in various organic synthesis processes. N-(4-(4-acetamido-3-nitrophenyl)-2-nitrophenyl)acetamide is composed of a central acetamide group with two nitrophenyl groups attached, one of which has an additional acetamido group. The presence of these functional groups suggests potential reactivity and applications in the fields of chemistry and materials science.

Uses

Used in Organic Synthesis:
N-(4-(4-acetamido-3-nitrophenyl)-2-nitrophenyl)acetamide is used as an intermediate in the synthesis of various organic compounds. Its unique structure and functional groups make it a valuable building block for creating a wide range of molecules with different properties and applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N-(4-(4-acetamido-3-nitrophenyl)-2-nitrophenyl)acetamide is used as a starting material for the development of new drugs. Its chemical properties and reactivity allow for the creation of novel drug candidates with potential therapeutic effects.
Used in Dye and Pigment Industry:
Due to its yellow solid appearance, N-(4-(4-acetamido-3-nitrophenyl)-2-nitrophenyl)acetamide can be used as a precursor in the production of dyes and pigments. Its chemical structure can be modified to produce a variety of colors, making it a versatile compound for this application.
Used in Research and Development:
N-(4-(4-acetamido-3-nitrophenyl)-2-nitrophenyl)acetamide is also utilized in research and development settings, where it can be employed to study the properties and behavior of similar compounds. Its unique structure makes it an interesting subject for scientific investigation, potentially leading to new discoveries and innovations in the field of chemistry.

Upstream product

• 613-35-4 N,N'-Diacetylbenzidin 
• 881-50-5 N-(4-bromo-2-nitrophenyl)acetamide 
• 99768-11-3 acetic acid-(4-dihydroxyboranyl-2-nitro-anilide) 
• 89942-26-7 N-(4-iodo-2-nitrophenyl)acetamide 
• 91-95-2 3,3',4,4'-tetraaminobiphenyl 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 
• 92-87-5 p,p'-diaminobiphenyl 
• 103-84-4 Acetanilid 

Downstream Products

• 1539-06-6 3-nitro-4-acetamidobenzoic acid 
• 32456-01-2 3.3'-dinitro-4'-amino-4-oxy-diphenyl 
• 6271-79-0 3,3'-dinitrobenzidine 
• 91-95-2 3,3',4,4'-tetraaminobiphenyl 

Relevant articles and documents

Synthesis method of benzidine compound

The invention discloses a synthesis method of a benzidine compound. A compound (I) is subjected to catalytic coupling reaction to obtain a compound (II); the compound (II) is subjected to alkaline oracidic hydrolysis reaction process to obtain a compound (III); the compound (III) is subjected to catalytic hydrogenation reduction reaction in an organic system to obtain a benzidine compound (V); orthe compound (II) is subjected to catalytic hydrogenation reduction reaction in an organic solvent to obtain a compound (V); the compound (V) is subjected to alkaline or acidic hydrolysis reaction toobtain a compound (IV). The method disclosed by the invention overcomes various defects of the existing method; the conventional commercial catalysts are used; the reaction time is greatly shortened;the capacity is improved. Noteworthily, the organic solvent can be recovered and reused; hydroiodic acid or hydrobromide generated through coupling reaction can be smoothly converted into iodides orbromide salts with high economic values through treatment. Therefore, the method disclosed by the invention is an economic easy-to-industrialize green method.

Design, synthesis, and anti-tumor evaluation of novel symmetrical bis-benzimidazoles

A novel symmetrical bis-benzimidazole was designed as DNA minor groove binder. Molecular modeling study showed that it could dock into the minor groove of DNA. Several derivatives were synthesized and confirmed by IR, MS, and 1H NMR. All these novel compounds were screened for cytotoxic activity on SKOV-3, HeLa, and BGC-823 cell lines in vitro. Some compounds showed IC50s in the single-digit micromolar range for cytotoxicity in several tumor cell lines.

Symmetric bis-benzimidazoles: New sequence-selective DNA-binding molecules

A series of bis-benzimidazole compounds with a head-to-head orientation have been designed as sequence-specific DNA binders; crystallographic analysis of oligonucleotide complexes has been combined with DNase I footprinting to confirm that the predicted optimal site for the core bisbenzimidazole motif is the four-base-pair sequence 5'-AATT; this sequence specificity results in inhibition of transcription at A/T sites and may be responsible for the cytotoxic and antitumour effects shown by these head-to-head bis-benzimidazoles.