63790-45-4

Basic information

• Product Name: 4H-1-Benzopyran-8-carboxaldehyde, 7-methoxy-4-oxo-2-phenyl-
• CAS NO: 63790-45-4
• Molecular Formula: C17H12O4
• Molecular Weight: 280.28
• Mol File: 63790-45-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4H-1-Benzopyran-8-carboxaldehyde, 7-methoxy-4-oxo-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1-Benzopyran-8-carboxaldehyde, 7-methoxy-4-oxo-2-phenyl-(63790-45-4)
• EPA Substance Registry System: 4H-1-Benzopyran-8-carboxaldehyde, 7-methoxy-4-oxo-2-phenyl-(63790-45-4)

Safety Data

• Hazardous Substances Data: 63790-45-4(Hazardous Substances Data)

Upstream product

• 42345-25-5 7-hydroxy-4-oxo-2-phenyl-4H-chromene-8-carbaldehyde 
• 77-78-1 dimethyl sulfate 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 52923-29-2 1-(2-hydroxy-4-methoxyphenyl)-3-phenylprop-2-en-1-one 
• 22395-22-8 7-methoxoyflavone 
• 108-46-3 recorcinol 
• 39103-37-2 7-benzoyloxy-2-phenyl-4H-1-benzopyran-4-one 
• 5465-06-5 <4-(benzoyloxy)-2-hydroxybenzoyl>benzoylmethane 
• 66832-97-1 2,4-dibenzoyloxyacetophenone 
• 6665-86-7 7-hydroxyflavone 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 

Relevant articles and documents

Synthesis and biological evaluation of flavone-8-acrylamide derivatives as potential multi-target-directed anti Alzheimer agents and investigation of binding mechanism with acetylcholinesterase

In a search for novel multifunctional anti-Alzheimer agents, a congeneric set of seventeen flavone-8-acrylamide derivatives (8a─q)were synthesized and evaluated for their cholinesterase inhibitory, antioxidant, neuroprotective and modulation of Aβ aggregation activities. The target compounds showed effective and selective inhibitory activity against the AChE over BuChE. In addition, the target compounds also showed moderate anti-oxidant activity and strong neuroprotective capacities, and accelerated dosage-dependently the Aβ aggregation. Also, we presented here a complete study on the interaction of 8a, 8d, 8e, 8h and 8i with AChE. Through fluorescence emission studies, the binding sites number found to be 1, binding constants were calculated as 2.04 × 104, 2.22 × 104, 1.18 × 104, 9.8 × 103 and 3.2 × 104 M?1 and free energy change as ?5.83, ?5.91, ?5.51, ?5.41 and ?6.12 kcal M?1 at 25 °C which were well agreed with the computational calculations indicating a strong binding affinity of flavones and AChE. Furthermore, the CD studies revealed that the secondary structure of AChE became partly unfolded upon binding with 8a, 8d, 8e, 8h and 8i.

Facile synthesis of 7-methoxy-2-aryl-3-phenyl/or-H-8-[2-(4,6-dimethyl-3,5- dicarbethoxy-pyridyl)]-4H-1-benzopyran-4-ones

Condensation of 8-formyl-7-methoxy-2-phenyl-4H-1-benzopyran-4-ones (5a-f) with ethyl-3-aminocrotonate (6) in glacial acetic acid under Hantzsch conditions afforded 7-methoxy-2-aryl-3-phenyl/or-H-8-[2-(4,6-dimethyl-3,5-dicarbethoxy- pyridyl)]-4H-1-benzopyran-4-ones (7a-f) in good yields. Copyright Taylor & Francis Group, LLC.