638-00-6Relevant articles and documents
-
Guilard et al.
, p. 195,202,203,206,210 (1971)
-
HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF
-
Paragraph 00284, (2013/08/28)
Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
Highly selective 5-substitution of 3-methylthiophene via directed lithiation
Smith, Keith,Barratt, Mark Lewis
, p. 1031 - 1034 (2008/02/04)
(Chemical Equation Presented) Lithiation of 3-methylthiophene with lithium 2,2,6,6-tetramethylpiperidide (LiTMP) is highly selective at the 5-position, and reaction with a range of electrophiles gives high yields of the corresponding 2,4-disubstituted thiophenes, even when unhindered electrophiles are used.