63812-15-7 Usage
Description
2-Fluoroisobutyric acid is an organic compound that features a fluorine atom attached to an isobutyric acid structure. It is known for its unique chemical properties, including reactivity and stability, which make it a valuable building block in the synthesis of various fluorinated compounds.
Uses
Used in Pharmaceutical Industry:
2-Fluoroisobutyric acid is used as a key intermediate in the synthesis of 2-fluoroisobutyric acid chloride, which is an important reactant in the production of 2-Fluoro-Acids, Esters, and Amides. These fluorinated compounds are valuable in the development of pharmaceuticals, particularly for the creation of novel drugs with improved pharmacokinetic and pharmacodynamic properties.
Used in Chemical Synthesis:
2-Fluoroisobutyric acid is used as a versatile building block in the synthesis of various organic compounds, including those derived from α-Dicyanoepoxides. Its unique fluorinated structure allows for the development of new chemical entities with potential applications in various industries, such as agrochemicals, materials science, and specialty chemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 63812-15-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,8,1 and 2 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 63812-15:
(7*6)+(6*3)+(5*8)+(4*1)+(3*2)+(2*1)+(1*5)=117
117 % 10 = 7
So 63812-15-7 is a valid CAS Registry Number.
InChI:InChI=1/C4H7FO2/c1-4(2,5)3(6)7/h1-2H3,(H,6,7)
63812-15-7Relevant articles and documents
Silver-catalyzed monofluoroalkylation of heteroarenes with α-fluorocarboxylic acids: an insight into the solvent effect
Dong, Yunhui,Guo, Chunfang,Han, Xuliang,Li, Xiangye,Li, Xinjin,Li, Yueyun,Liu, Hui,Liu, Zhaolong,Zhang, Lizhi
supporting information, p. 1147 - 1150 (2022/02/03)
A mild and efficient method for direct C-H monofluoroalkylation of heteroarenes with easily accessible and inexpensive α-fluorocarboxylic acids has been developed. This silver-catalyzed reaction affords mono- and bis-monofluoroalkylated heteroarenes in good yields under mild conditions, and the solvent effect on the monofluoroalkylation reaction is discussed in detail.
Synthesis of 2-fluoro- acids, esters, and amides from α-dicyanoepoxides
Amanetoullah, A. Ould,Chaabouni,Baklouti
, p. 1155 - 1161 (2007/10/03)
The opening of α-dicyanoepoxides by pyridine polyhydrofluoride yields polymerisable 2-fluorocyanoformyls which may be kept intact when diluated in dichloromethane or ether. These intermediates react with nucleophiles such as water, methanol or amines to give respectively 2-fluoroacids, esters or amides.