638218-78-7

Basic information

• Product Name: 2-(6-broMopyridin-2-yl)propan-2-ol
• Synonyms: 2-(6-broMopyridin-2-yl)propan-2-ol
• CAS NO: 638218-78-7
• Molecular Formula: C₈H₁₀BrNO
• Molecular Weight: 216.0751
• Mol File: 638218-78-7.mol
• Article Data: 32

Chemical Properties

• Boiling Point: 273.2±25.0 °C(Predicted)
• Appearance: /
• Density: 1.474±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 13.23±0.29(Predicted)
• CAS DataBase Reference: 2-(6-broMopyridin-2-yl)propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(6-broMopyridin-2-yl)propan-2-ol(638218-78-7)
• EPA Substance Registry System: 2-(6-broMopyridin-2-yl)propan-2-ol(638218-78-7)

Safety Data

• Hazardous Substances Data: 638218-78-7(Hazardous Substances Data)

Usage

General Description

2-(6-bromopyridin-2-yl)propan-2-ol is a chemical compound with the molecular formula C8H10BrNO. It is an alcohol that contains a bromine-substituted pyridine ring. 2-(6-broMopyridin-2-yl)propan-2-ol is commonly used in organic synthesis and pharmaceutical research as a building block for various drugs and biologically active compounds. It may also be used as a reagent in chemical reactions to introduce the bromine atom into specific positions on other molecules. Additionally, 2-(6-bromopyridin-2-yl)propan-2-ol has potential applications in the development of new materials and as a precursor for the synthesis of complex organic compounds.

Upstream product

• 49669-13-8 1-(6-bromopyridin-2-yl)-ethanone 
• 676-58-4 methylmagnesium chloride 
• 26218-75-7 methyl 6-Bromopicolinate 
• 75-16-1 methylmagnesium bromide 
• 626-05-1 2,6-Dibromopyridine 
• 67-64-1 acetone 
• 917-64-6 methyl magnesium iodide 

Downstream Products

• 955369-56-9 2-allyl-1-(6-(2-hydroxypropane-2-yl)pyridin-2-yl)-6-((4-(4-methylpiperazine)-1-yl)phenyl)amino-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one 
• 955365-80-7 MK-1775 
• 1446791-07-6 6-((1R,2S)-2-aminocyclohexylamino)-4-(6-(2-hydroxypropan-2-yl)pyridin-2-ylamino)pyridazine-3-carboxamide 
• 1446793-34-5 tert-butyl (1S,2R)-2-(6-carbamoyl-5-(6-(2-hydroxypropan-2-yl)pyridin-2-ylamino)pyridazin-3-ylamino)cyclohexylcarbamate 

Relevant articles and documents

PYRAZOLONE FORMYL PEPTIDE 2 RECEPTOR AGONISTS

The disclosure relates to compounds of formula I, which are formyl peptide 2 (FPR2) receptor agonists. The disclosure also provides compositions and methods of using the compounds, for example, for the treatment of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.

PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER

The invention provides compounds of the formula (1): or a salt or tautomer thereof wherein A, R1, R2, R3, R4, R5 and R6 are as defined herein. The compounds are inhibitors of Wee1 and/or PLK1 kinase and are envisaged to be useful in the treatment of cancers.

Efficient access to quinolines and quinazolines by ruthenium complexes catalyzed acceptorless dehydrogenative coupling of 2-aminoarylmethanols with ketones and nitriles

Treatment of N,N,O-tridentate pyrazolyl-pyridinyl-alcohol ligands, 2-(CR1R2OH)-6-[3,5-(R3)2C3HN2]C5H3N (R1 = R2 = Me, R3 = H (L1H); R1 = Me, R2 = Ph, R3 = H (L2H); R1 = R2 = Ph, R3 = H (L3H); R1 = R2 = R3 = Me (L4H)) with RuCl3?xH2O in refluxing EtOH afforded the corresponding Ru(III) complexes L2RuCl (1a-1d), which were well characterized by IR, HR-MS and X-ray single crystal structural determination. These Ru complexes showed similarly high catalytic performance for both dehydrogenative couplings of 2-aminoarylmethanols with ketones and nitriles, giving the quinolines and quinazolines in good to excellent yields. This protocol provides an atom-economical and sustainable route to access various structurally important quinoline and quinazoline derivatives by using phosphine-free ligand based Ru catalysts.