6383-02-4 Usage
Description
2,4-bis(benzyloxy)-1-methoxybenzene, also known as 1-Methoxy-2,4-bis(phenylmethoxy)benzene, is an organic compound that serves as a key intermediate in the synthesis of various bioactive molecules. It is characterized by the presence of methoxy and benzyloxy functional groups attached to a benzene ring, which contribute to its reactivity and potential applications in chemical synthesis.
Uses
Used in Pharmaceutical Industry:
2,4-bis(benzyloxy)-1-methoxybenzene is used as a reactant in the synthesis of Lamellarin D, a potent inhibitor of topoisomerase. 2,4-bis(benzyloxy)-1-methoxybenzene has potential applications in the development of anticancer drugs, as topoisomerase inhibitors are known to interfere with the replication and transcription of DNA in cancer cells, leading to their death.
Additionally, 2,4-bis(benzyloxy)-1-methoxybenzene can be utilized in the synthesis of other bioactive compounds with potential therapeutic applications, making it a valuable building block in the pharmaceutical industry. Its versatility in chemical reactions and ability to form various derivatives make it a promising candidate for further research and development in drug discovery.
Check Digit Verification of cas no
The CAS Registry Mumber 6383-02-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,3,8 and 3 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 6383-02:
(6*6)+(5*3)+(4*8)+(3*3)+(2*0)+(1*2)=94
94 % 10 = 4
So 6383-02-4 is a valid CAS Registry Number.
6383-02-4Relevant articles and documents
Total Synthesis of Lamellarins G, J, L, and Z Using One-Pot Halogen Dance/Negishi Coupling
Mori, Atsunori,Morii, Kazuki,Morikawa, Daiki,Okano, Kentaro,Yasuda, Yuto
, p. 13388 - 13401 (2021/10/12)
A bottom-up synthesis of lamellarins G, J, L, and Z was achieved via one-pot halogen dance/Negishi coupling of a lithiated dibromopyrrole derivative. The easily accessible dibromopyrrole bearing an ester moiety underwent halogen dance smoothly at -78 °C within 10 min. The resultant α-pyrrolyllithium was transmetalated to the corresponding organozinc species, which was then coupled with an aryl iodide in the presence of catalytic palladium to provide the fully substituted pyrrole. Subsequent halogen-lithium exchange was performed to incorporate a boronate group exclusively at the β position proximal to the ester moiety. This synthetic intermediate allowed stepwise diarylation for the total synthesis of lamellarins G, J, L, and Z.
Facile synthesis of polyhydroxycoumaronochromones with quinones: Synthesis of alkylpolyhydroxy- and alkoxycoumaronochromones from 2′-hydroxyisoflavones
Tsukayama, Masao,Oda, Akihiro,Kawamura, Yasuhiko,Nishiuchi, Masaki,Yamashita, Kazuyo
, p. 6163 - 6166 (2007/10/03)
4′,5,7-Trihydroxy- or 8-alkyl-4′,5,7-trihydroxycoumaronochromones were synthesized by oxidative cyclization of the corresponding 2′-hydroxyisoflavones with o-chloranil under mild conditions. By contrast, alkoxycoumaronochromones were synthesized by oxidative cyclization of the corresponding 2′-hydroxyisoflavones with DDQ.
