639008-17-6

Basic information

• Product Name: 2-hydroxy-2-(4-nitrophenyl)ethanesulfonic acid isopropyl ester
• Synonyms: 2-hydroxy-2-(4-nitrophenyl)ethanesulfonic acid isopropyl ester
• CAS NO: 639008-17-6
• Molecular Weight: 289.309
• Mol File: 639008-17-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-hydroxy-2-(4-nitrophenyl)ethanesulfonic acid isopropyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-2-(4-nitrophenyl)ethanesulfonic acid isopropyl ester(639008-17-6)
• EPA Substance Registry System: 2-hydroxy-2-(4-nitrophenyl)ethanesulfonic acid isopropyl ester(639008-17-6)

Safety Data

• Hazardous Substances Data: 639008-17-6(Hazardous Substances Data)

Upstream product

• 926-06-7 isopropyl methanesulfonate 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 639008-10-9 N-{4-[2-(benzylmethylsulfamoyl)ethyl]phenyl}-N-(2,2-dimethoxyethyl)-2,2,2-trifluoroacetamide 
• 639008-15-4 2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonic acid benzylmethylamide 
• 639008-14-3 2-[3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-yl]ethanesulfonic acid benzylmethylamide 
• 639008-12-1 2-[1-(2,2,2-trifluoroacetyl)-1H-indol-5-yl]ethanesulfonic acid benzylmethylamide 
• 639008-09-6 2-{4-[(2,2-dimethoxyethyl)-(2,2,2-trifluoroacetyl)amino]phenyl}ethanesulfonic acid isopropyl ester 
• 639008-08-5 2-[4-(2,2-dimethoxyethylamino)phenyl]ethanesulfonic acid benzylmethylamide 
• 639008-13-2 N-benzyl-2-(1H-indole-5-yl)-N-methylethane-1-sulfonamide 
• 639008-07-4 2-[4-(2,2-dimethoxyethylamino)phenyl]ethanesulfonic acid isopropyl ester 
• 639008-03-0 2-(4-aminophenyl)ethanesulfonic acid benzylmethylamide 
• 639008-01-8 2-(4-nitrophenyl)ethenesulfonic acid benzylmethylamide 
• 639008-02-9 2-(4-aminophenyl)ethanesulfonic acid isopropyl ester 
• 121679-13-8 naratriptan 
• 52148-00-2 trans-2-(p-nitrophenyl)ethenesulfonyl chloride 
• 98593-83-0 2-(4-aminophenyl)ethanesulfonic acid 

Relevant articles and documents

Synthesis of 5-substituted indole derivatives. Part 4: Naratriptan from α-anilinoacetaldehyde dimethylacetal by TiCl4-mediated cyclisation

N-Methyl-3-(1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide (Naratriptan, 2) was prepared from N-methyl-N-phenylmethyl-2-(4-aminophenyl)-ethanesulfonamide (3b) through reductive alkylation with dimethoxyacetaldehyde followed by N-acylation and TiCl4-mediated indolisation, according to Sundberg procedure. The isopropyl group proved to be a useful protecting group for sulfonate esters in a number of transformations but was cleaved in the presence of TiCl4.