63913-20-2

Basic information

• Product Name: 5-Nitro-1-(5-nitro-2-pyridyl)-2-pyridone
• Synonyms: 5-Nitro-1-(5-nitro-2-pyridyl)-2-pyridone
• CAS NO: 63913-20-2
• Molecular Weight: 262.181
• Mol File: 63913-20-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-Nitro-1-(5-nitro-2-pyridyl)-2-pyridone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Nitro-1-(5-nitro-2-pyridyl)-2-pyridone(63913-20-2)
• EPA Substance Registry System: 5-Nitro-1-(5-nitro-2-pyridyl)-2-pyridone(63913-20-2)

Safety Data

• Hazardous Substances Data: 63913-20-2(Hazardous Substances Data)

Upstream product

• 4548-45-2 2-chloro-5-nitropyridine 

Relevant articles and documents

Synthesis of 6-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones via directed lithiation of 2-substituted 5-aminopyridine derivatives

Directed lithiation of Boc or pivaloyl derivatives of 2-substituted 5-aminopyridines with BuLi-TMEDA in diethyl ether at -10°C gave 4-lithio derivatives which were quenched with CO2 to give the analogous C-4 carboxylic acids. Hydrolysis of the protecting groups with either TFA or aqueous KOH gave 2-substituted 5-aminopyridine-4-carboxylic acids which were converted to 6-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones by reaction with formamide or, more optimally, formamidine acetate. Boc protected aminopyridines provided the best overall results, with synthesis of these derivatives best achieved by direct reaction of the aminopyridine with di-tert-butyl dicarbonate in the absence of added base.